Treatment-resistant depression (TRD) continues to pose a major medical challenge,
as up to 20% of patients with major depressive disorder (MDD) fail to achieve response
despite adequate trials of antidepressant drugs, psychotherapy, and electroconvulsive
therapy (ECT), leading to severe disability. Deep brain stimulation (DBS), a procedure
that involves the direct implantation of stimulation electrodes in localized brain
regions with the aim of modulating local and connected abnormal hyperactivity, has
recently been gaining momentum as an alternative treatment modality for TRD.
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References
- Deep brain stimulation for treatment-resistant depression.Neuron. 2005; 45: 651-660
- Subcallosal cingulated gyrus deep brain stimulation for treatment-resistant depression.Biol Psychiatry. 2008; 64: 461-467
- ECT in a patient with a deep brain-stimulating electrode in place.J ECT. 2000; 16: 287-290
- Electroconvulsive therapy for depression in a Parkinson's disease patient with bilateral subthalamic nucleus deep brain stimulators.Parkinsonism Relat Disord. 2005; 11: 403-406
- Bitemporal electroconvulsive therapy for depression in a Parkinson disease patient with a deep-brain stimulator.J ECT. 2008; 24: 171-172
- Is alexithymia the emotional equivalent of blindsight?.Biol Psychiatry. 1997; 42: 834-844
Article info
Publication history
Published online: May 12, 2009
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© 2009 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
