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Depressive Relapse After Initial Response to Subcallosal Cingulate Gyrus-Deep Brain Stimulation in a Patient with a Treatment-Resistant Depression: Electroconvulsive Therapy as a Feasible Strategy

  • Dolors Puigdemont
    Affiliations
    Department of Psychiatry, Hospital de la Santa Creu i Sant, Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Centro de Investigación, Biomédica en Red de Salud Mental (CIBERSAM), Spain
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  • Maria J. Portella
    Affiliations
    Psychiatry Department, Hospital de la Santa Creu i Sant Pau, Centro de Investigación Biomédica en Red de Salut Mental-CIBERSAM, Sant Antoni Ma. Claret, 167, 08025, Barcelona, Catalonia, Spain
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  • Rosario Pérez-Egea
    Affiliations
    Department of Psychiatry, Hospital de la Santa Creu i Sant, Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Centro de Investigación, Biomédica en Red de Salud Mental (CIBERSAM), Spain
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  • Javier de Diego-Adeliño
    Affiliations
    Department of Psychiatry, Hospital de la Santa Creu i Sant, Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Centro de Investigación, Biomédica en Red de Salud Mental (CIBERSAM), Spain
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  • Alex Gironell
    Affiliations
    Department of Neurology, Hospital de la Santa Creu i Sant, Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
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  • Joan Molet
    Affiliations
    Department of Neurology, Hospital de la Santa Creu i Sant, Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
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  • Santiago Duran-Sindreu
    Affiliations
    Department of Psychiatry, Hospital de la Santa Creu i Sant, Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Centro de Investigación, Biomédica en Red de Salud Mental (CIBERSAM), Spain

    Neuropsychiatry Unit, Hospital de la Mare de Déu de la Mercè, Germanes Hospitalàries del Sagrat Cor de Jesús, Barcelona, Spain
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  • Enric Álvarez
    Affiliations
    Department of Psychiatry, Hospital de la Santa Creu i Sant, Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Centro de Investigación, Biomédica en Red de Salud Mental (CIBERSAM), Spain
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  • Víctor Pérez
    Affiliations
    Department of Psychiatry, Hospital de la Santa Creu i Sant, Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Centro de Investigación, Biomédica en Red de Salud Mental (CIBERSAM), Spain
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      Treatment-resistant depression (TRD) continues to pose a major medical challenge, as up to 20% of patients with major depressive disorder (MDD) fail to achieve response despite adequate trials of antidepressant drugs, psychotherapy, and electroconvulsive therapy (ECT), leading to severe disability. Deep brain stimulation (DBS), a procedure that involves the direct implantation of stimulation electrodes in localized brain regions with the aim of modulating local and connected abnormal hyperactivity, has recently been gaining momentum as an alternative treatment modality for TRD.
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