Correspondence| Volume 66, ISSUE 3, e3, August 01, 2009

Improving Methodology Improves Timing: Reply to Thombs et al.

      We thank Thombs and colleagues for their close reading of our article, which has identified an issue related to the inclusion and coding of “dummy” variables for certain effects. By prompting a reexamination of our data, their letter has helped to clarify further the role of post–acute coronary syndrome (ACS) depression.
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      Linked Article

      • Timing May Be Important, but Methodology Is Everything: A Commentary on Parker et al.
        Biological PsychiatryVol. 66Issue 3
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          Parker et al. (1) argued that in predicting cardiac readmission or death following an acute coronary syndrome (ACS), “Timing is everything.” On the basis of multivariate logistic regression, they reported that patients who developed a depressive episode in the month following an ACS admission, whether incident or recurrent, had on average 7 times the odds (95% confidence interval [CI] = 2.21–22.17) for ACS readmission or cardiac mortality compared with patients with no depression before or after the ACS.
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