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Commentary| Volume 65, ISSUE 9, P725-727, May 01, 2009

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Primary Process Affects and Brain Oxytocin

  • Jaak Panksepp
    Correspondence
    Address reprint requests to Jaak Panksepp, Ph.D., Department of VCAPP, College of Veterinary Medicine, Washington State University, PO Box 646520, Pullman, WA 99164-6520
    Affiliations
    Department of VCAPP, College of Veterinary Medicine, Washington State University, Pullman, Washington
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      Fascinating findings about intranasal oxytocin effects in humans continue to emerge. Periodically, we should take stock of the overall meaning of these findings and seek new connections to therapeutic issues. Indeed, thoughtful integration with the full spectrum of animal research findings may help bring greater order to the diverse findings being harvested in humans.
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      References

        • Ditzen B.
        • Schaer M.
        • Gabriel B.
        • Bodenmann G.
        • Ehlert U.
        • Heinrichs M.
        Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict.
        Biol Psychiatry. 2008; 65: 728-731
        • Freud S.
        [The Interpretation of Dreams].
        Liepzig and Wien, Franz Deuticke1900
        • Panksepp J.
        Affective Neuroscience: The Foundations of Human and Animal Emotions.
        Oxford University Press, New York1998
        • Pedersen C.A.
        Biological aspects of social bonding and the roots of human violence.
        Ann N Y Acad Sci. 2004; 1036: 106-127
        • Kendrick K.M.
        Oxytocin, motherhood and bonding.
        Exp Physiol. 2000; 85: 111S-124S
        • Nelson E.
        • Panksepp J.
        Oxytocin and infant-mother bonding in rats.
        Behav Neurosci. 1996; 110: 583-592
        • Uvnäs-Moberg K.
        Physiological and endocrine effects of social contacts.
        Ann N Y Acad Sci. 1997; 807: 146-163
        • Liberzon I.
        • Trujillo K.A.
        • Akil H.
        • Young E.A.
        Motivational properties of oxytocin in the conditioned place preference paradigm.
        Neuropsychopharmacology. 1997; 17: 353-359
        • Panksepp J.
        • Nelson E.
        • Bekkedal M.
        Brain systems for the mediation of social separation-distress and social-reward.
        Ann N Y Acad Sci. 1997; 807: 78-100
        • Panksepp J.
        • Herman B.H.
        • Vilberg T.
        • Bishop P.
        • DeEskinazi F.G.
        Endogenous opioids and social behavior.
        Neurosci Biobehav Rev. 1980; 4: 473-487
        • Olmstead M.C.
        • Franklin K.B.
        The development of a conditioned place preference to morphine: Effects of microinjections into various CNS sites.
        Behav Neurosci. 1997; 111: 1324-1334
        • Herman B.H.
        • Panksepp J.
        Ascending endorphinergic inhibition of distress vocalization.
        Science. 1981; 211: 1060-1062
        • Kovács G.L.
        • Sarnyai Z.
        • Szabó G.
        Oxytocin and addiction: A review.
        Psychoneuroendocrinology. 1998; 23: 945-962
        • Bodkin A.
        • Zornberg G.L.
        • Lukas S.E.
        • Cole J.O.
        Buprenorphine treatment of refractory depression.
        J Clin Psychopharmacol. 1995; 15: 49-57
        • Panksepp J.
        Oxytocin effects on emotional processes: Separation distress, social bonding, and relationships to psychiatric disorders.
        Ann N Y Acad Sci. 1992; 652: 243-252
        • McCarthy M.M.
        • Low L.M.
        • Pfaff D.W.
        Speculations concerning the physiological significance of central oxytocin in maternal behavior.
        Ann N Y Acad Sci. 1992; 652: 70-82
        • Riters L.V.
        • Panksepp J.
        Effects of vasotocin on aggressive behavior in male Japanese quail.
        Ann N Y Acad Sci. 1997; 807: 478-480
        • Bartz J.A.
        • Hollander E.
        Oxytocin and experimental therapeutics in autism.
        Prog Brain Res. 2008; 170: 451-462
      1. Watt D, Panksepp J (in press): The depressive matrix: An evolutionarily conserved mechanism to terminate separation distress? A review of aminergic, peptidergic and neural network perspectives. Neuropsychoanalysis 11:5–104.

        • Kose S.
        • Pincus D.I.
        • Arana A.
        • Johnson K.A.
        • Anderson B.S.
        • Morgan P.
        • et al.
        Oxytocin for treating depression: A double blind placebo controlled neuroimaging study.
        Biol Psychiatry. 2008; 63: 206S
        • Meinlschmidt G.
        • Heim C.
        Sensitivity to intranasal oxytocin in adult men with early parental separation.
        Biol Psychiatry. 2007; 61: 1109-1111
        • Norberg M.M.
        • Krystal J.H.
        • Tolin D.F.
        A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy.
        Biol Psychiatry. 2008; 63: 1118-1126
        • Panksepp J.
        • Harro J.
        The future of neuropeptides in biological psychiatry and emotional psychopharmacology: Goals and strategies.
        in: Panksepp J. Textbook of Biological Psychiatry. Wiley, Hoboken, NJ2004: 627-660