Cross-species approaches are potentially useful for identifying genes influencing complex traits, including susceptibility to human psychiatric disorders. Donner et al
. (pages 672–680) tested 13 genes previously shown to be differentially expressed between anxious and non-anxious mouse strains as candidate genes for human anxiety disorders with a genetic association study. The results revealed some evidence for association of ALAD
with risk for social phobia, DYNLL2
with risk for generalized anxiety disorder, and PSAP
with risk for panic disorder.