Background
This study aims to estimate the risk of developing stroke within 5 years of discharge
among young patients ages 18 to approximately 44 who were hospitalized for depressive
disorders.
Methods
Our study design features a study cohort and a comparison cohort. The study cohort
included patients ages 18 to approximately 44 who were hospitalized with a principal
diagnosis of depressive disorder (n = 827), whereas the comparison cohort consisted of 4,135 patients selected randomly
(five for every depressed patient) and matched with the study group in terms of gender,
age, and date of discharge. Each patient was tracked for 5 years after their discharge
in 1998. Cox proportional hazard regressions were performed to compute the 5-year
stroke-free survival rates after adjusting for possible confounding factors.
Results
During the 5-year follow-up period, 50 depressed patients (6.05% of the study cohort)
and 48 non-depressed subjects (1.16% of the comparison cohort) developed strokes.
The adjusted hazard of stroke was 5.43 (95% confidence interval = 3.47–8.51, p < .001) times greater for depressed patients than for non-depressed subjects.
Conclusions
Our findings show young patients ages 18 to approximately 44 who were hospitalized
for depressive disorders were at over five times greater risk of developing stroke
within 5 years of discharge compared with non-depressed age- and gender-matched subjects.
Key Words
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Article info
Publication history
Published online: August 22, 2008
Accepted:
July 6,
2008
Received in revised form:
June 30,
2008
Received:
May 5,
2008
Identification
Copyright
© 2008 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
