The basal ganglia (BG) are traditionally considered to process information in parallel
and segregated functional streams consisting of reward processing, cognition, and
motor control areas. Moreover, microcircuits within the ventral striatum are associated
with different aspects of reward processing (
1
). However, a key component for developing appropriate behavioral-guiding rules is
the ability not only to evaluate different aspects of reward correctly, including
value versus risk and predictability, but to inhibit maladaptive choices on the basis
of previous experience. This requires integration between different aspects of reward
processing as well as interaction with cognitive control regions. Indeed, an emerging
literature demonstrates the complexity of the network in which there is a dual organizational
system, permitting both parallel and integrative network processing. This has particular
relevance for chronic drug use, in which initial use activates the ventral striatum
but, over time, the dorsal corticodorsal BG system becomes involved (
2
). The Sharf et al., (pages 175–183), Pissios et al., (pages 184–191), and Makris et al. (pages 192–202) articles in this issue nicely illustrate this duel concept in which
changes occur following drug administration within specific parts of the reward system
and across reward and cognitive systems.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Accepted:
May 30,
2008
Received in revised form:
May 30,
2008
Received:
May 28,
2008
Identification
Copyright
© 2008 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
