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Abnormal Corpus Callosum Integrity in Bipolar Disorder: A Diffusion Tensor Imaging Study

  • Fei Wang
    Correspondence
    Address reprint requests to Fei Wang, M.D., Ph.D., Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511
    Affiliations
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

    Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut
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  • Jessica H. Kalmar
    Affiliations
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

    Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut
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  • Elliot Kale Edmiston
    Affiliations
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

    Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut
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  • Lara G. Chepenik
    Affiliations
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

    Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut
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  • Zubin Bhagwagar
    Affiliations
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
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  • Linda Spencer
    Affiliations
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

    Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut
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  • Brian Pittman
    Affiliations
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
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  • Marcel Jackowski
    Affiliations
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut

    Institute of Mathematics and Statistics, University of São Paulo, Brazil
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  • Xenophon Papademetris
    Affiliations
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut

    Department of Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut
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  • R. Todd Constable
    Affiliations
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut

    Department of Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut

    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut
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  • Hilary P. Blumberg
    Affiliations
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut

    Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut
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      Objective

      Abnormalities in the anterior interhemispheric connections provided by the corpus callosum (CC) have long been implicated in bipolar disorder (BD). In this study, we used complementary diffusion tensor imaging methods to study the structural integrity of the CC and localization of potential abnormalities in BD.

      Methods

      Subjects included 33 participants with BD and 40 healthy comparison participants. Fractional anisotropy (FA) measures were compared between groups with region of interest (ROI) methods to investigate the anterior, middle, and posterior CC and voxel-based methods to further localize abnormalities.

      Results

      In ROI-based analyses, FA was significantly decreased in the anterior and middle CC in the BD group (p < .05). Voxel-based analyses similarly localized group differences to the genu, rostral body, and anterior midbody of CC (p < .05, corrected).

      Conclusion

      The findings demonstrate abnormalities in the structural integrity of the anterior CC in BD that might contribute to altered interhemispheric connectivity in this disorder.

      Key Words

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      References

        • Starr M.A.
        Organic Nervous Disease.
        Lea Brothers and Company, New York and Philadelphia1903
        • Coffman J.A.
        • Bornstein R.A.
        • Olson S.C.
        • Schwarzkopf S.B.
        • Nasrallah H.A.
        Cognitive impairment and cerebral structure by MRI in bipolar disorder.
        Biol Psychiatry. 1990; 27: 1188-1196
        • Atmaca M.
        • Ozdemir H.
        • Yildirim H.
        Corpus callosum areas in first-episode patients with bipolar disorder.
        Psychol Med. 2007; 37: 699-704
        • Yurgelun-Todd D.A.
        • Silveri M.M.
        • Gruber S.A.
        • Rohan M.L.
        • Pimentel P.J.
        White matter abnormalities observed in bipolar disorder: A diffusion tensor imaging study.
        Bipolar Disord. 2007; 9: 504-512
        • Brambilla P.
        • Nicoletti M.
        • Sassi R.B.
        • Mallinger A.G.
        • Frank E.
        • Keshavan M.S.
        • et al.
        Corpus callosum signal intensity in patients with bipolar and unipolar disorder.
        J Neurol Neurosurg Psychiatry. 2004; 75: 221-225
        • First M.B.
        • Spitzer R.L.
        • Gibbon M.
        • Williams J.B.W.
        Structured Clinical Interview for DSM-IV Axis I & II Disorders (Version 2.0).
        New York State Psychiatric Institute, New York1995
        • Williams J.B.W.
        • Link M.J.
        • Rosenthal N.E.
        • Terman M.
        Structured Interview Guide for the Hamilton Depression Rating Scale: Seasonal Affective Disorder Version (SIGH-SAD).
        New York State Psychiatric Institute, New York1994
        • Altman E.G.
        • Hedeker D.R.
        • Janicak P.G.
        • Peterson J.L.
        • Davis J.M.
        The Clinician-Administered Rating Scale for Mania (CARS-M): Development, reliability, and validity.
        Biol Psychiatry. 1994; 36: 124-134
        • Hollingshead A.B.
        Two Factor Index of Social Position.
        Yale University Press, New Haven, Connecticut1957
        • Basser P.J.
        • Mattiello J.
        • LeBihan D.
        Estimation of the effective self-diffusion tensor from the NMR spin echo.
        J Magn Reson B. 1994; 103: 247-254
        • Meisenzahl E.M.
        • Frodl T.
        • Greiner J.
        • Leinsinger G.
        • Maag K.P.
        • Heiss D.
        • et al.
        Corpus callosum size in schizophrenia—a magnetic resonance imaging analysis.
        Eur Arch Psychiatry Clin Neurosci. 1999; 249: 305-312
        • Bruder G.E.
        • Schnur D.B.
        • Fergeson P.
        • Mukherjee S.
        • Leite P.
        • Sackeim H.A.
        Dichotic-listening measures of brain laterality in mania.
        J Abnorm Psychol. 1994; 103: 758-766
        • Pettigrew J.D.
        • Miller S.M.
        A ‘sticky’ interhemispheric switch in bipolar disorder?.
        Proc Biol Sci. 1998; 265: 2141-2148
        • Schmahmann J.D.
        • Pandya D.N.
        Fiber Pathways of the Brain.
        Oxford University Press, New York2006
        • Blumberg H.P.
        • Leung H.C.
        • Skudlarski P.
        • Lacadie C.M.
        • Fredericks C.A.
        • Harris B.C.
        • et al.
        A functional magnetic resonance imaging study of bipolar disorder: State- and trait-related dysfunction in ventral prefrontal cortices.
        Arch Gen Psychiatry. 2003; 60: 601-609
        • Snook L.
        • Plewes C.
        • Beaulieu C.
        Voxel based versus region of interest analysis in diffusion tensor imaging of neurodevelopment.
        Neuroimage. 2007; 34: 243-252
        • Brown E.S.
        Management of comorbid bipolar disorder and substance abuse.
        J Clin Psychiatry. 2006; 67: e05
        • DeLisi L.E.
        • Bertisch H.C.
        • Szulc K.
        • Majcher M.
        • Brown K.
        • Bappal A.
        • et al.
        A preliminary DTI study showing no brain structural change associated with adolescent cannabis use.
        Harm Reduct J. 2006; 3: 7
        • Pfefferbaum A.
        • Sullivan E.V.
        • Hedehus M.
        • Adalsteinsson E.
        • Lim K.O.
        • Moseley M.
        In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism.
        Alcohol Clin Exp Res. 2000; 24: 1214-1221
        • Keshavan M.S.
        • Diwadkar V.A.
        • DeBellis M.
        • Dick E.
        • Kotwal R.
        • Rosenberg D.R.
        • et al.
        Development of the corpus callosum in childhood, adolescence and early adulthood.
        Life Sci. 2002; 70: 1909-1922