Background
The dopamine D3 receptor (DRD3) is suspected to modulate prepulse inhibition (PPI) in animals and humans, but definite
conclusions cannot be drawn due to lack of selective DRD3 ligands. The Ser9Gly polymorphism is a common variant of the DRD3 gene and determines the gain of function of the D3 receptor. This is the first study to examine the influence of the DRD3 Ser9Gly polymorphism on human PPI.
Methods
Prepulse inhibition was measured in 101 healthy male subjects presented with 75-dB
and 85-dB prepulses at 30-, 60-, and 120-msec prepulse-pulse intervals. Subjects were
grouped according to their DRD3 status into a Gly/Gly, a Ser/Gly, and a Ser/Ser group.
Results
Analyses of variance showed that at all prepulse and interval conditions, Gly/Gly
individuals had the lowest PPI and the greatest onset latency facilitation and Ser/Ser
individuals had the highest PPI and the lowest onset latency facilitation, while Ser/Gly
individuals were intermediate.
Conclusions
These results suggest that PPI is modulated by the D3 receptor and its levels depend on the Ser9Gly polymorphism.
Key Words
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Article info
Publication history
Published online: March 06, 2008
Accepted:
January 27,
2008
Received in revised form:
January 2,
2008
Received:
October 15,
2007
Identification
Copyright
© 2008 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
