Background
Mutations in the PINK1 gene can cause Parkinson's disease and are frequently associated with psychiatric
symptoms that might even precede motor signs.
Methods
To determine whether specific gray matter degeneration of limbic and frontal structures
might be liable to different psychiatric symptoms in PINK1 mutation carriers, observer-independent voxel-based morphometry was applied to high-resolution
magnetic resonance images of 14 PINK1 mutation carriers from a large German family and 14 age- and gender-matched healthy
control subjects.
Results
Psychiatric diagnoses in PINK1 mutation carriers comprised major depression without psychotic symptoms and schizophrenia-spectrum,
panic, adjustment, and obsessive-compulsive personality disorders. As hypothesized,
the categorical comparison between all PINK1 mutation carriers and control subjects demonstrated atrophy of limbic structures,
especially the hippocampus and parahippocampus. More specifically, multiple regression
analysis considering all psychiatric subscores simultaneously displayed different
frontal (prefrontal, dorsolateral, and premotor cortex) and limbic (parahippocampus
and cingulate) degeneration patterns. The duration of the psychiatric disease was
also correlated with the extent of limbic and frontal gray matter volume decrease.
Conclusions
Our results support the hypothesis that limbic and frontal gray matter alterations
could explain various psychiatric symptoms observed in PINK1 mutation carriers. Factors determining individual susceptibility to degeneration
of certain brain areas remain to be elucidated in future studies.
Key Words
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Article info
Publication history
Published online: February 13, 2008
Accepted:
December 14,
2007
Received in revised form:
December 11,
2007
Received:
August 27,
2007
Footnotes
The first two authors contributed equally to the study.
Identification
Copyright
© 2008 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
