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Brief Report| Volume 64, ISSUE 3, P252-255, August 01, 2008

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Plasma Obestatin Concentrations Are Negatively Correlated with Body Mass Index, Insulin Resistance Index, and Plasma Leptin Concentrations in Obesity and Anorexia Nervosa

  • Toshihiro Nakahara
    Correspondence
    Address reprint requests to Toshihiro Nakahara, M.D., Ph.D., Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima-City 890-8520, Japan
    Affiliations
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, and Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima-City, Japan
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  • Toshiro Harada
    Affiliations
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, and Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima-City, Japan
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  • Daisuke Yasuhara
    Affiliations
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, and Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima-City, Japan
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  • Nobuhiro Shimada
    Affiliations
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, and Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima-City, Japan
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  • Haruka Amitani
    Affiliations
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, and Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima-City, Japan
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  • Takeo Sakoguchi
    Affiliations
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, and Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima-City, Japan
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  • Mayra Mayumi Kamiji
    Affiliations
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, and Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima-City, Japan

    Department of Gastroenterology, Faculty of Medicine, University of Sao Paulo, Ribeirão Preto Campus, Ribeirão Preto, Brazil.
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  • Akihiro Asakawa
    Affiliations
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, and Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima-City, Japan
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  • Akio Inui
    Affiliations
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, and Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima-City, Japan
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      Background

      Obestatin is a recently identified ghrelin gene product that was reported to inhibit appetite and gastric motility in contrast to ghrelin. We investigated fasting obestatin and ghrelin levels in patients with obesity and anorexia nervosa.

      Methods

      Fasting plasma obestatin, acyl-ghrelin, desacyl-ghrelin, leptin, glucose serum adiponectin, and insulin were measured in 10 obese subjects, 11 restricting-type anorexics, and 11 control subjects.

      Results

      Obese group had significantly lower levels of obestatin (p < .01), while anorexic group had significantly higher levels (p < .01). Obestatin was negatively correlated with body mass index (BMI) (r = −.74), glucose (r = −.56), insulin (r = −.55), leptin (r = −.66), and also with the homeostasis model assessment of insulin resistance (HOMA-R) (r = −.49) and was positively correlated with acyl-ghrelin (r = .65) and desacyl-ghrelin (r = .60). No correlation was seen between obestatin and adiponectin, but the latter was negatively correlated with both acyl-ghrelin and desacyl-ghrelin. Desacyl-ghrelin to acyl-ghrelin ratio was significantly different between anorexic and control groups (p < .05), while no difference was seen between obese and control groups.

      Conclusions

      Both obestatin and ghrelin are increased in anorexic and decreased in obesity. We suggest that obestatin is a nutritional marker reflecting body adiposity and insulin resistance.

      Key Words

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