Several major psychiatric disorders, including schizophrenia, bipolar disorder, and
autism, have been shown to have strong underlying genetic components and are among
the most heritable of genetically complex medical illnesses. However, 30 years of
psychiatric genetics research demonstrates that high heritability does not mean ease
of finding genetic causes. Indeed, the history of psychiatric genetics is largely
a story of unreplicated discoveries and unrealized expectations. At the risk of raising
expectations once again, this disappointing history may be about to change, and a
new chapter of discovery may be about to begin.
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© 2007 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
