Although the validity of attention deficit hyperactivity disorder (ADHD) as medical
disorder has been widely questioned in the media, the past two decades have produced
a wealth of data supporting the idea that ADHD, which affects 8–12% of children worldwide
(
Faraone et al 2003
) and 3 to 5% of adults (
Faraone and Biederma 2005
), is a highly heritable condition (
Faraone et al 2005
) with documented brain abnormalities in both children and adults (
Faraone 2004
). Although these data meet standard criteria for asserting the validity of ADHD as
a medical disorder (
Faraone 2005
), they have not completely described the etiology and pathophysiology of the disorder.
Fortunately, as the current issue of Biological Psychiatry shows, new research in ADHD is mapping out details of known pathophysiologic pathways
and pointing to new directions for research.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Impaired temporal resolution of visual attention and dopamine beta hydroxylase genotype in attention-deficit/hyperactivity disorder.Biol Psychiatry. 2006; 60: 1039-1045
- Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function.Biol Psychiatry. 2006; 60: 1111-1120
- Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder.Biol Psychiatry. 2006; 60: 1053-1061
- Characterizing cognition in ADHD: beyond executive dysfunction.Trends Cogn Sci. 2006; 10: 117-123
- Attention-deficit/hyperactivity disorder endophenotypes.Biol Psychiatry. 2005; 57: 1324-1335
- Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for attention-deficit hyperactivity disorder.Biol Psychiatry. 2006; 60: 1062-1070
- Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes.Am J Psychiatry. 1995; 152: 1286-1290
- Etiology and pathophysiology of adult attention deficit hyperactivity disorder.Primary Psychiatry. 2004; 11: 28-40
- The scientific foundation for understanding attention-deficit/hyperactivity disorder as a valid psychiatric disorder.Eur Child Adolesc Psychiatry. 2005; 14: 1-10
- What is the prevalence of adult ADHD?.J Atten Disord. 2005; 9: 384-391
- Diagnosing adult ADHD: are late onset and subthreshold diagnoses valid?.Am J Psychiatry. 2006; 163: 1720-1729
- Meta-analysis of the association between the 7-repeat allele of the dopamine d(4) receptor gene and attention deficit hyperactivity disorder.Am J Psychiatry. 2001; 158: 1052-1057
- Molecular genetics of attention deficit hyperactivity disorder.Biol Psychiatry. 2005; 57: 1313-1323
- The worldwide prevalence of ADHD: is it an American condition?.World Psychiatry. 2003; 2: 104-113
Faraone SV, WIlens TE, Petty C, Antshel K, Spencer T, Biederman J (in press): Substance use disorders among ADHD adults: implications of late onset and subthreshold diagnoses. Am J Addict.
- The endophenotype concept in psychiatry: etymology and strategic intentions.Am J Psychiatry. 2003; 160: 636-645
- Association between DRD4 gene and performance of children with ADHD in a test of sustained attention.Biol Psychiatry. 2006; 60: 1163-1165
- Intra-subject variability in attention-deficit hyperactivity disorder.Biol Psychiatry. 2006; 60: 1088-1097
- Joint analysis of DRD5 marker concludes association with ADHD confined to the predominantly inattentive and combined subtypes.Am J Hum Genet. 2004; 74: 348-356
- Meta-analysis of family-based association studies between the dopamine transporter gene and attention deficit hyperactivity disorder.Psychiatr Genet. 2005; 15: 53-59
- Rodent models of attention-deficit/hyperactivity disorder.Biol Psychiatry. 2005; 57: 1239-1247
- Association between alpha-2a-adrenergic receptor gene and ADHD inattentive type.Biol Psychiatry. 2006; 60: 1028-1033
- Dorsolateral prefrontal and anterior cingulate cortex volumetric abnormalities in adults with attention-deficit/hyperactivity disorder identified by magnetic resonance imaging.Biol Psychiatry. 2006; 60: 1071-1080
- A single nucleotide polymorphism at DBH, possibly associated with attention-deficit/hyperactivity disorder, associates with lower plasma dopamine-hydroxylase activity and is in linkage disequilibrium with two putative functional single nucleotide polymorphisms.Biol Psychiatry. 2006; 60: 1034-1038
- The Genetics of Mood Disorders. The John Hopkins University Press, Baltimore1990
Valera EM, Faraone SV, Murray KE, Seidman LJ (in press): Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder. Biol Psychiatry.
- Validity of the executive function theory of ADHD: a meta-analytic review.Biol Psychiatry. 2005; 57: 1336-1346
Article info
Identification
Copyright
© 2006 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.