Original Article| Volume 62, ISSUE 4, P321-326, August 15, 2007

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Overweight and Obesity Affect Treatment Response in Major Depression


      Epidemiologic and clinical studies suggest comorbidity between major depressive disorder (MDD) and obesity. To elucidate the impact of weight on the course of depression beyond comorbidity, we investigated psychopathology, attention, neuroendocrinology, weight change, and treatment response in MDD patients, depending on their weight.


      Four hundred eight inpatients with MDD participated in the Munich Antidepressant Response Signature Study, designed to discover biomarkers and genotypes that are predictive for clinical outcome. Psychopathology and anthropometric parameters were monitored weekly in 230 patients. In subsamples, combined dexamethasone–corticotropin-releasing hormone and attention tests were conducted at admission and discharge. One thousand twenty-nine diagnosed matched controls served for morphometric comparisons.


      Patients with MDD had a significantly higher body mass index (BMI) compared with healthy controls. Patients with high BMI (≥25) showed a significantly slower clinical response, less improvement in neuroendocrinology and attention, and less weight gain than did patients with normal BMI (18.5 ≤ BMI < 25) during antidepressant treatment.


      Our findings suggest that overweight and obesity characterize a subgroup of MDD patients with unfavorable treatment outcome.

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      • Errata
        Biological PsychiatryVol. 62Issue 4
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          In the online version of “Overweight and Obesity Affect Treatment Response in Major Depression” by Kloiber et al. that originally became available as an article-in-press on January 22, 2007, there were some errors in Table 3. The “(d2)” was mistakenly typeset next to “Divided attention,” but should have been set next to “Selective attention” in the first column, first row. Also, in the third column, Standard deviations data were erroneously reported instead of Standard errors. The table has since been corrected, and the correct version of Table 3 now appears in the article online, as well as in this print issue of Biological Psychiatry (Biol Psychiatry 2007;62:321-326).
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