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Lack of Empirical Reference Data for In Vivo Magnetic Resonance Spectroscopic Glutamate Measurements in Humans

Published:December 11, 2006DOI:https://doi.org/10.1016/j.biopsych.2006.05.049
      Theberge et al. (2002) question the variability and accuracy of our recent magnetic resonance spectroscopy (MRS) findings of increased glutamate (Glu) signals in the prefrontal cortex and the hippocampus of patients with recurrent schizophrenia (
      • Tebartz van Elst L.
      • Valerius G.
      • Büchert M.
      • Thiel T.
      • Bubl E.
      • Ruesch N.
      • et al.
      Increased prefrontal and hippocampal glutamate concentration in schizophrenia Evidence from a magnetic resonance spectroscopy study.
      ). We do not think that these criticisms are substantial and want to respond to their concerns point by point.
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      References

        • Govindaraju V.
        • Young K.
        • Maudsley A.A.
        Proton NMR chemical shifts and coupling constants for brain metabolites.
        NMR Biomed. 2000; 13: 129-153
        • Klunk W.E.
        • Xu C.
        • Panchalingam K.
        • McClure R.J.
        • Pettegrew J.W.
        Quantitative 1H and 31P MRS of PCA extracts of postmortem Alzheimer’s disease brain.
        Neurobiol Aging. 1996; 17: 349-357
        • Mark L.P.
        • Prost R.W.
        • Ulmer J.L.
        • Smith M.M.
        • Daniels D.L.
        • Strottmann J.M.
        • et al.
        Pictorial review of glutamate excitotoxicity: Fundamental concepts for neuroimaging.
        AJNR Am J Neuroradiol. 2001; 22: 1813-1824
        • Michaelis T.
        • Merboldt K.D.
        • Bruhn H.
        • Hanicke W.
        • Frahm J.
        Absolute concentrations of metabolites in the adult human brain in vivo: Quantification of localized proton MR spectra.
        Radiology. 1993; 187: 219-227
        • Provencher S.W.
        Estimation of metabolite concentration from localized in vivo proton NMR spectra.
        Magn Reson Imag. 1993; 30: 672-679
        • Schubert F.
        • Seifert F.
        • Leopold K.
        • Krebs M.
        • Schaefer M.
        • Gallinat J.
        Proton MRS at 3 Tesla in brain of schizophrenic patients: Elevated glutamate and reduced NAA in hippocampus.
        Proc Intl Soc Mag Reson Med. 2006; 14: 3151
        • Siegel G.J.
        • Agranaoff B.W.
        • Albers R.W.
        • Molinoff P.
        Basic Neurochemistry: Molecular, Cellular, and Medical Aspects. Raven Press, New York1989
        • Tebartz van Elst L.
        • Thiel T.
        • Hesslinger B.
        • Lieb K.
        • Bohus M.
        • Hennig J.
        • et al.
        Subtle prefrontal neuropathology in a pilot magnetic resonance spectroscopy study in patients with borderline personality disorder.
        J Neuropsychiatry Clin Neurosci. 2001; 13: 511-514
        • Tebartz van Elst L.
        • Valerius G.
        • Büchert M.
        • Thiel T.
        • Bubl E.
        • Ruesch N.
        • et al.
        Increased prefrontal and hippocampal glutamate concentration in schizophrenia.
        Biol Psychiatry. 2005; 58: 724-730
        • Theberge J.
        • Al Semaan Y.
        • Williamson P.C.
        • Menon R.S.
        • Neufeld R.W.
        • Rajakumar N.
        • et al.
        Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS.
        Am J Psychiatry. 2003; 160: 2231-2233
        • Theberge J.
        • Bartha R.
        • Drost D.J.
        • Menon R.S.
        • Malla A.
        • Takhar J.
        • et al.
        Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers.
        Am J Psychiatry. 2002; 159: 1944-1946
        • Van Zijl P.C.
        • Barker P.B.
        Magnetic resonance spectroscopy and spectroscopic imaging for the study of brain metabolism.
        Ann N Y Acad Sci. 1997; 820: 75-96