Theberge et al. (2002) question the variability and accuracy of our recent magnetic resonance spectroscopy
(MRS) findings of increased glutamate (Glu) signals in the prefrontal cortex and the
hippocampus of patients with recurrent schizophrenia (
Tebartz van Elst et al 2005
). We do not think that these criticisms are substantial and want to respond to their
concerns point by point.To read this article in full you will need to make a payment
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References
- Proton NMR chemical shifts and coupling constants for brain metabolites.NMR Biomed. 2000; 13: 129-153
- Quantitative 1H and 31P MRS of PCA extracts of postmortem Alzheimer’s disease brain.Neurobiol Aging. 1996; 17: 349-357
- Pictorial review of glutamate excitotoxicity: Fundamental concepts for neuroimaging.AJNR Am J Neuroradiol. 2001; 22: 1813-1824
- Absolute concentrations of metabolites in the adult human brain in vivo: Quantification of localized proton MR spectra.Radiology. 1993; 187: 219-227
- Estimation of metabolite concentration from localized in vivo proton NMR spectra.Magn Reson Imag. 1993; 30: 672-679
- Proton MRS at 3 Tesla in brain of schizophrenic patients: Elevated glutamate and reduced NAA in hippocampus.Proc Intl Soc Mag Reson Med. 2006; 14: 3151
- Basic Neurochemistry: Molecular, Cellular, and Medical Aspects. Raven Press, New York1989
- Subtle prefrontal neuropathology in a pilot magnetic resonance spectroscopy study in patients with borderline personality disorder.J Neuropsychiatry Clin Neurosci. 2001; 13: 511-514
- Increased prefrontal and hippocampal glutamate concentration in schizophrenia.Biol Psychiatry. 2005; 58: 724-730
- Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS.Am J Psychiatry. 2003; 160: 2231-2233
- Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers.Am J Psychiatry. 2002; 159: 1944-1946
- Magnetic resonance spectroscopy and spectroscopic imaging for the study of brain metabolism.Ann N Y Acad Sci. 1997; 820: 75-96
Article info
Publication history
Published online: December 11, 2006
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© 2007 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
