Lack of Empirical Reference Data for In Vivo Magnetic Resonance Spectroscopic Glutamate Measurements in Humans

Published:December 11, 2006DOI:
      Theberge et al. (2002) question the variability and accuracy of our recent magnetic resonance spectroscopy (MRS) findings of increased glutamate (Glu) signals in the prefrontal cortex and the hippocampus of patients with recurrent schizophrenia (
      • Tebartz van Elst L.
      • Valerius G.
      • Büchert M.
      • Thiel T.
      • Bubl E.
      • Ruesch N.
      • et al.
      Increased prefrontal and hippocampal glutamate concentration in schizophrenia Evidence from a magnetic resonance spectroscopy study.
      ). We do not think that these criticisms are substantial and want to respond to their concerns point by point.
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