The vascular depression hypothesis was formulated in 1997 and postulated that cerebrovascular disease can predispose, precipitate, or perpetuate a depressive syndrome in older adults. The term “vascular depression” encompassed entities with diverse pathogenetic mechanisms. The original article argued that “direct testing of the vascular depression hypothesis is not possible since the mechanisms of depression are unknown” (
Alexopoulos et al 1997). The hypothesis was viewed, however, as the intellectual platform for studies of the clinical presentation, outcomes, pathogenesis, and treatment of a subgroup of geriatric individuals with depression.
- Alexopoulos G.S.
- Meyers B.S.
- Young R.C.
- Campbell S.
- Silbersweig D.
- Charlson M.
The “vascular depression” hypothesis.
Arch Gen Psychiatry. 1997; 54: 915-922
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