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Commentary| Volume 60, ISSUE 12, P1306-1308, December 15, 2006

Vascular Depression: An Archetypal Neuropsychiatric Disorder

      Neurologists are trained to detect subtle sensorimotor deficits as manifestations of stroke. The slightest facial asymmetry, a faintly clumsy hand, the minimal visual field defect of a superior quadrantanopsia, transient perioral numbness, or even slight slurring of speech are correctly elicited and identified as telltale signs of stroke requiring urgent treatment. Nevertheless, when the relatives of an older patient mention the recent occurrence of changes in behavior, mood, or cognition—profound apathy, anger, uncharacteristic aggressiveness, depression, problems completing domestic tasks—most stroke neurologists exhibit an enlarged blind spot to these “nonneurological” prefrontal manifestations. The symptoms are either summarily dismissed off or, in the best of cases, referred to a psychiatrist for evaluation.
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      References

        • Alexander G.E.
        • Delong M.R.
        • Strick P.L.
        Parallel organization of functionally segregated circuits linking basal ganglia and cortex.
        Annu Rev Neurosci. 1986; 9: 357-381
        • Alexopoulos G.S.
        “The depression-executive dysfunction syndrome of late life”: A specific target for D3 agonists?.
        Am J Geriatr Psychiatry. 2001; 9: 22-29
        • Alexopoulos G.S.
        • Meyers B.S.
        • Young R.C.
        • Campbell S.
        • Silbersweig D.
        • Charlson M.
        “Vascular depression” hypothesis.
        Arch Gen Psychiatry. 1997; 54: 915-922
        • Arciniegas D.B.
        New-onset bipolar disorder in late life: A case of mistaken identity.
        Am J Psychiatry. 2006; 163: 198-203
        • Bousser M.G.
        • Tournier-Lasserve E.
        Summary of the proceedings of the First International Workshop on CADASIL.
        Stroke. 1994; 25: 704-707
        • Carson A.J.
        • MacHale S.
        • Allen K.
        • Lawrie S.M.
        • Dennis M.
        • House A.
        • Sharpe M.
        Depression after stroke and lesion location: a systematic review.
        Lancet. 2000; 356: 122-126
        • Charlton R.A.
        • Morris R.G.
        • Nitkunan A.
        • Markus H.S.
        The cognitive profiles of CADASIL and sporadic small vessel disease.
        Neurology. 2006; 66: 1523-1526
        • Cummings J.L.
        Frontal–subcortical circuits and human behavior.
        Arch Neurol. 1993; 50: 585-589
        • Cummings J.L.
        • Arciniegas D.B.
        • Brooks B.R.
        • Herndon R.M.
        • Lauterbach E.C.
        • Pioro E.P.
        • et al.
        Defining and diagnosing involuntary emotional expression disorder.
        CNS Spectr. 2006; 11: 1-7
        • Depp C.A.
        • Jeste D.V.
        Bipolar disorder in older adults: a critical review.
        Bipolar Disord. 2004; 6: 343-367
        • Hackett M.L.
        • Yapa C.
        • Parag V.
        • Anderson C.S.
        Frequency of depression after stroke: A systematic review of observational studies.
        Stroke. 2005; 36: 1330-1340
        • Levy R.
        • Dubois B.
        Apathy and the functional anatomy of the prefrontal cortex–basal ganglia circuits.
        Cerebral Cortex. 2006; 16: 916-928
        • Longstreth Jr, W.T.
        • Bernick C.
        • Manolio T.
        • Bryan N.
        • Jungreis C.A.
        • Price T.R.
        Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: The Cardiovascular Health Study.
        Arch Neurol. 1998; 55: 1217-1225
        • O’Sullivan M.
        • Barrick T.R.
        • Morris R.G.
        • Clark C.A.
        • Markus H.S.
        Damage within a network of white matter regions underlies executive dysfunction in CADASIL.
        Neurology. 2005; 65: 1584-1590
        • Parvizi J.
        • Anderson S.W.
        • Martin C.O.
        • Damasio H.
        • Damasio A.R.
        Pathological laughter and crying: A link to the cerebellum.
        Brain. 2001; 124: 1708-1719
        • Peters N.
        • Holtmannspotter M.
        • Opherk C.
        • Gschwendtner A.
        • Herzog J.
        • Samann P.
        • Dichgans M.
        Brain volume changes in CADASIL: A serial MRI study in pure subcortical ischemic vascular disease.
        Neurology. 2006; 66: 1517-1522
        • Prins N.D.
        • van Dijk E.J.
        • den Heijer T.
        • Vermeer S.E.
        • Jolles J.
        • Koudstaal P.J.
        • et al.
        Cerebral small-vessel disease and decline in information processing speed, executive function and memory.
        Brain. 2005; 128: 2034-2041
        • Román G.C.
        Facts, myths, and controversies in vascular dementia.
        J Neurol Sci. 2004; 226: 49-52
        • Román G.C.
        • Royall D.R.
        Executive control function: A rational basis for the diagnosis of vascular dementia.
        Alzheimer Dis Assoc Disord. 1999; 13: S69-S80
        • Román G.C.
        • Sachdev P.
        • Royall D.R.
        • Bullock R.A.
        • Orgogozo J.M.
        • Lopez-Pousa S.
        • et al.
        Vascular cognitive disorder: A new diagnostic category updating vascular cognitive impairment and vascular dementia.
        J Neurol Sci. 2004; 226: 81-87
        • Román G.C.
        • Tatemichi T.K.
        • Erkinjuntti T.
        • Cummings J.L.
        • Masdeu J.C.
        • Garcia J.H.
        • et al.
        Vascular dementia: Diagnostic criteria for research studies.
        Neurology. 1993; 43: 250-260
        • Royall D.R.
        “Silent Stroke”: An oxymoron meaning “dementia.”.
        Semin Cerebrovasc Dis Stroke. 2004; 4: 97-101
        • Sajatovic M.
        • Blow F.C.
        • Ignacio R.V.
        • Kales H.C.
        New-onset bipolar disorder in later life.
        Am J Geriatr Psychiatry. 2005; 13: 282-289
        • Vataja R.
        • Leppavuori A.
        • Pohjasvaara T.
        • Mantyla R.
        • Aronen H.J.
        • Salonen O.
        • et al.
        Poststroke depression and lesion location revisited.
        J Neuropsychiatry Clin Neurosci. 2004; 16: 156-162
        • Vataja R.
        • Pohjasvaara T.
        • Mantyla R.
        • Ylikoski R.
        • Leskela M.
        • Kalska H.
        • et al.
        Depression–executive dysfunction syndrome in stroke patients.
        Am J Geriatr Psychiatry. 2005; 13: 99-107
        • Vermeer S.E.
        • Koudstaal P.J.
        • Oudkerk M.
        • Hofman A.
        • Breteler M.M.B.
        Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study.
        Stroke. 2002; 33: 21-25
        • Vermeer S.E.
        • Prins N.D.
        • den Heijer T.
        • Hofman A.
        • Koudstaal P.J.
        • Breteler M.M.
        Silent brain infarcts and the risk of dementia and cognitive decline.
        N Engl J Med. 2003; 348: 1215-1222
        • WHO
        The International Classification of Impairments, Disabilities and Handicaps. World Health Organization (reprinted 1993), Geneva1980