Background
Variation in the gene for dopamine β-hydroxylase (DβH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective
self-report. This association has yet to be tested prospectively.
Methods
Visual analog scale (VAS) ratings of paranoia were obtained in 31 cocaine users during
three cocaine self-administration sessions (8, 16, and 32 mg/70kg). Pharmacogenetic
interactions between cocaine and a putative functional polymorphism in DβH (-1021C→T) were assessed.
Results
VAS self-ratings showed significant or trend-level interactions of genotype and time
during each session (p = .004, .09 and .003, respectively) with TT homozygotes endorsing greater paranoia
over time than either CT or CC individuals. Interactions were significant at all doses
in African Americans (n = 19; p = .02, .04 and .05). No other demographic or experimental variable distinguished
genotypic groups.
Conclusions
Results indicate that individuals homozygous for the ‘very low-activity’ T allele
at DβH -1021C→T show an increased propensity to paranoia over time during cocaine self-administration.
Key Words
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Article info
Publication history
Published online: December 08, 2006
Accepted:
August 17,
2006
Received in revised form:
August 16,
2006
Received:
June 12,
2006
Identification
Copyright
© 2007 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
