Background
Converging evidence has demonstrated an association between the Disrupted in Schizophrenia
1 (DISC1) gene and schizophrenia (SZ). Within the DISC1 gene, a single nucleotide
polymorphism (SNP), Ser704Cys, has been associated with the structure and function
of the hippocampus. Because positive symptoms in SZ have also been associated with
hippocampal structure and function, we hypothesized that variation in a DISC1 haplotype
containing Ser704Cys would be significantly associated with positive symptomatology
in SZ.
Methods
We tested for an association between variation in a haplotype block within the DISC1
gene containing Ser704Cys and lifetime history of positive symptoms in 199 Caucasian
patients with SZ.
Results
We detected significant associations between a DISC1 haplotype containing Ser704Cys
and Ser704Cys genotype and lifetime severity of delusions in SZ.
Conclusions
These data suggest that that the effect of DISC1 genetic variation might be associated
with positive symptoms in patients with SZ.
Key Words
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Article info
Publication history
Published online: October 20, 2006
Accepted:
July 19,
2006
Received in revised form:
June 21,
2006
Received:
April 6,
2006
Identification
Copyright
© 2007 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
