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Testosterone Levels and Sexual Maturation Predict Substance Use Disorders in Adolescent Boys: A Prospective Study

Published:November 26, 2006DOI:https://doi.org/10.1016/j.biopsych.2006.07.008

      Background

      This investigation determined whether testosterone level and sexual maturation in boys biased development of socially nonnormative behavior culminating in a substance use disorder (SUD).

      Methods

      The subjects were 179 boys recruited in late childhood through a high-risk paradigm. Path analysis was used to evaluate the influence of testosterone level and sexual maturation in early adolescence (age 12–14) on attitudes toward antisociality, affiliation with deviant peers, and social potency in middle adolescence (age 16), illicit drug use by late adolescence (age 19), and SUD in young adulthood (age 22).

      Results

      Testosterone level predicted social potency and approval of aggressive/antisocial behavior. Sexual maturation mediated the relation between testosterone level in early adolescence and later affiliation with deviant peers. Social potency, approval of aggressive/antisocial behavior, and deviant peer affiliations predicted illicit drug use by late adolescence that in turn predicted SUD in young adulthood.

      Conclusions

      This study demonstrated that pubertal processes in early adolescence influence the risk for SUD via effects on psychosocial functioning.

      Key Words

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      References

        • Allen J.
        • Porter M.
        • McFarland F.
        • Marsh P.
        • McElhaney K.
        The two facets of adolescents’ success with peers: Adolescent popularity, social adaptation, and deviant behavior.
        Child Dev. 2005; 76: 747-760
        • Andersson T.
        • Magnusson D.
        Biological maturation in adolescence and the development of drinking habits and alcohol abuse among young males: A prospective longitudinal study.
        J Youth Adolesc. 1990; 19: 33-41
        • Archer J.
        Testosterone and human aggression: An evaluation of the challenge hypothesis.
        Neurosci Biobehav Rev. 2006; 30: 319-345
        • Booth A.
        • Osgood D.
        The influence of testosterone on deviance in adulthood.
        Criminology. 1993; 31: 93-117
        • Clark D.B.
        • Cornelius J.R.
        • Kirisci L.
        • Tarter R.E.
        Childhood risk categories for adolescent substance involvement: A general liability typology.
        Drug Alcohol Depend. 2005; 77: 13-21
        • Clark D.B.
        • Pollock N.K.
        • Mezzich A.
        • Cornelius J.
        • Martin C.
        Diachronic assessment and the emergence of substance use disorders.
        J Child Adolesc Subst Abuse. 2001; 10: 13-22
        • Clausen J.A.
        The social meaning of differential physical and sexual maturation.
        in: Dragstin S.E. Elder G.H. Adolescence in the Life Cycle Psychological Change and Social Context. Hemisphere, Washington, DC1975: 25-47
        • Dabbs Jr, J.M.
        • Hopper C.H.
        • Jurkovic G.J.
        Testosterone and personality among college students and military veterans.
        Pers Individ Dif. 1990; 11: 1263-1269
        • Dawes M.
        • Antelman S.
        • Vanyukov M.
        • Giancola P.
        • Tarter R.
        • Sussman E.
        • et al.
        Developmental sources of variation in liability to adolescent substance use disorder.
        Drug Alcohol Depend. 2000; 61: 3-14
        • Duncan P.D.
        • Ritter P.L.
        • Dornbusch S.M.
        • Gross R.T.
        • Carlsmith J.M.
        The effects of pubertal timing on body image, school behavior, and deviance.
        J Youth Adolesc. 1985; 14: 227-235
        • Elkins I.
        • McGue M.
        • Malone S.
        • Iacono W.
        The effect of parental alcohol and drug disorders on adolescent personality.
        Am J Psychiatry. 2004; 161: 670-676
        • First M.B.
        • Spitzer R.L.
        • Gibbon M.
        • Williams J.B.
        The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) Clinician Version. American Psychiatric Press, Washington, DC1997
        • Graber J.A.
        • Brooks-Gunn J.
        Biological and maturational factors in development.
        in: Van Hasselt V.B. Henson M. Handbook of Adolescent Psychopathology: A Guide to Diagnosis and Treatment. Lexington Books, New York1995: 69-101
        • Graber J.A.
        • Seeley J.R.
        • Brooks-Gunn J.
        • Lewinsohn P.M.
        Is pubertal timing associated with psychopathology in young adulthood?.
        J Am Acad Child Adolesc Psychiatry. 2004; 43: 718-726
        • Hollingshead A.
        Four-Factor Index of Social Status. Yale University, New Haven, Connecticut1989
        • Kaltiala-Heino R.
        • Marttunen M.
        • Rantanen P.
        • Rimpela M.
        Early puberty is associated with mental health problems in middle adolescence.
        Soc Sci Med. 2003; 57: 1055-1064
        • Kirillova G.P.
        • Vanyukov M.M.
        • Gavaler J.S.
        • Pajer K.
        • Tarter R.E.
        Substance abuse in parents and their adolescent offspring: The role of sexual maturation and sensation seeking.
        J Child Adolesc Subst Abuse. 2001; 10: 77-89
        • Kirisci L.
        • Vanyukov M.
        • Tarter R.
        Identification of two latent trajectory classes culminating in early age onset substance use disorders.
        Psychol Addict Behav. 2005; 19: 243-252
        • Leckman J.
        • Sholomaskas D.
        • Thompson W.
        Best estimate of lifetime psychiatric diagnosis: A methodological study.
        Arch Gen Psychiatry. 1982; 39: 879-883
        • Loeber R.
        Peer Delinquency Scale. Pittsburgh Youth Study, Department of Psychiatry, University of Pittsburgh, Pittsburgh1989 ([unpublished])
        • Loeber R.
        Perception of Problem Behaviors Scale. Pittsburgh Youth Study, Department of Psychiatry, University of Pittsburgh, Pittsburgh1989 ([unpublished])
        • Magnusson D.
        • Stattin H.
        • Allen V.
        Biological maturation and social development.
        J Youth Adolesc. 1985; 14: 267-283
        • Marshall W.
        • Tanner I.
        Variation in the pattern of pubertal changes in boys.
        Arch Dis Child. 1970; 5: 13-23
        • Mazur A.
        Biosocial models of deviant behavior among army veterans.
        Biol Psychol. 1995; 41: 271-293
        • Mazur A.
        • Booth A.
        Testosterone and dominance in men.
        Behav Brain Sci. 1998; 21: 353-397
        • Moss H.
        • Lynch K.
        • Hardie T.
        Affiliation with deviant peers among children of substance dependent fathers from pre-adolescence into adolescence: Associations with problem behaviors.
        Drug Alcohol Depend. 2003; 71: 117-125
        • Muller M.N.
        • Wrangham R.W.
        Dominance, aggression and testosterone in wild chimpanzees: A test of the “challenge” hypothesis.
        Anim Behav. 2004; 67: 113-123
        • Mussen P.H.
        • Jones M.C.
        Self-conception, motivations, and interpersonal attitudes of late- and early-maturing boys.
        Child Dev. 1957; 28: 243-256
        • Muthen B.O.
        • Muthen L.K.
        Mplus User’s Guide. Muthen and Muthen, Los Angeles2001
        • Olweus D.
        • Mattson A.
        • Schalling D.
        • Low H.
        Testosterone, aggression, physical and personality dimensions in normal adolescent males.
        Psychosom Med. 1980; 42: 253-269
        • Patton G.
        • McMorris B.
        • Toumbourou J.
        • Hemphill S.
        • Donath S.
        • Catalano R.
        Puberty and the onset of substance use and abuse.
        Pediatrics. 2004; 114: 300-306
        • Schaal N.
        • Tremblay R.E.
        • Soussignan R.
        • Susman E.J.
        Male testosterone linked to high social dominance but low physical aggression in early adolescence.
        J Am Acad Child Adolesc Psychiatry. 1996; 34: 1322-1330
        • Schulltheiss O.C.
        • Dargel A.
        • Rohde W.
        Implicit motives and gonadal steroid hormones: Effects of menstrual cycle phase, oral contraceptive use, and relationship status.
        Horm Behav. 2003; 43: 293-301
        • Simmons R.G.
        • Blyth D.A.
        • Van Cleave E.F.
        • Bush D.M.
        Entry into early adolescence: The impact of school structure, puberty, and early dating on self-esteem.
        Am Sociol Rev. 1979; 44: 948-967
        • Sobel M.E.
        Asymptotic confidence intervals for indirect effects in structural equations models.
        in: Leinhart S. Sociological Methodology. Jossey-Bass, San Francisco1982: 290-312
        • Strong R.K.
        • Dabbs J.R.J.M.
        Testosterone and behavior in normal young children.
        Pers Individ Dif. 2000; 28: 909-915
        • Tarter R.
        Evaluation and treatment of adolescent substance abuse: A decision tree method.
        Am J Drug Alcohol Abuse. 1990; 16: 1-46
        • Tarter R.
        • Vanyukov M.
        • Giancola P.
        • Dawes M.
        • Blackson T.
        • Mezzich A.
        • et al.
        Etiology of early age onset substance use disorder: A maturational perspective.
        Dev Psychopathol. 1999; 11: 657-683
        • Tellegen A.
        Brief Manual for the Differential Personality Questionnaire. Psychology Department; University of Minnesota, Minneapolis, Minnesota1982 ([unpublished])
        • Udry J.R.
        Biosocial models of adolescent problem behaviors.
        Soc Biol. 1990; 37: 1-10
        • Vanyukov M.
        • Tarter R.
        • Kirisci L.
        • Kirillova G.
        • Maher B.
        • Clark D.
        Liability to substance use disorders. 1.
        Neurosci Biobehav Rev. 2003; 27: 507-515
        • Williams J.M.
        • Dunlop L.C.
        Pubertal timing and self-reported delinquency among male adolescents.
        J Adolesc. 1999; 22: 157-171