Background
Schizophrenia is a complex psychiatric disorder with a strong genetic component. Past
linkage studies have implicated several chromosomal regions in the etiology of schizophrenia.
Within these regions, several genes have been identified via candidate gene association
studies as strong schizophrenia susceptibility loci, including DAO, DAOA, DISC1, DTNBP1,
and RGS4.
Methods
The present study attempted to replicate these association findings by analyzing a
total of 120 markers across these genes in 311 schizophrenia subjects, 140 schizoaffective
subjects, and 291 control subjects.
Results
Our study found no association for DAOA and DTNBP1 with schizophrenia. Although no
association was seen with DAOA and DTNBP1, several other markers in the other genes
resulted in significant association with schizophrenia (p < .05). However, after a conservative Bonferroni correction for multiple testing,
only one marker, rs3918346, within DAO remained significant (odds ratio = 1.71, confidence
interval = 1.32–2.22, p = 4 × 10−5). This significant association was concordant with previous DAO genetic findings.
Conclusions
Our results significantly support DAO as a susceptibility locus for schizophrenia
and offer some support for the implication of both RGS4 and DISC1 in the etiology
of schizophrenia. However, we see no evidence to support either DAOA or DTNBP1 as
schizophrenia disease loci.
Key Words
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Article info
Publication history
Published online: October 23, 2006
Accepted:
July 13,
2006
Received in revised form:
July 12,
2006
Received:
June 7,
2006
Identification
Copyright
© 2007 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
