Background
Washing symptoms in Obsessive-Compulsive Disorder (OCD) are associated with increased
trait sensitivity to disgust. This study explored neural systems underlying sensitivity
to symptom-unrelated disgust and fear in OCD using functional neuroimaging.
Methods
Seventeen OCD subjects and 19 controls viewed facial expressions of disgust and fear
(versus neutral) presented just above the level of conscious awareness in a backward
masking paradigm.
Results
The OCD group showed greater activation than controls in the left ventrolateral prefrontal
cortex, but reduced activation in the thalamus, to facial expressions of disgust.
There were no between-group differences in response to fear. Further analysis using
a median-split to divide OCD subjects into high and low washers suggested that the
enhanced ventrolateral prefrontal cortex response was being driven by predominantly
female OCD subjects with high washing symptoms. These subjects also reported higher
levels of trait sensitivity to disgust.
Conclusions
These findings are consistent with previous reports of increased response to symptom-relevant
and generally disgusting stimuli in neural regions associated with disgust and autonomic
response processing in OCD patients with prominent washing symptoms. Together, these
findings point to increased sensitivity to disgust stimuli as a component of the pathophysiology
of the washing/contamination symptom dimension of OCD.
Key Words
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References
- An inventory for measuring depression.Arch Gen Psychiatry. 1961; 4: 561-571
- Response and habituation of the human amygdala during visual processing of facial expression.Neuron. 1996; 17: 875-887
- Computer-enhanced emotion in facial expressions.Proc R Soc Lond B. 1997; 264: 919-925
- Neuropsychology of fear and loathing.Nat Rev Neurosci. 2001; 2: 352-363
- Amygdala responses to human faces in obsessive-compulsive disorder.Biol Psychiatry. 2004; 56: 916-920
- AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.Comput Biomed Res. 1996; 29: 162-173
- Neural systems supporting interoceptive awareness.Nature Neurosci. 2004; 7: 189-195
- Pictures of facial affect. Consulting Psychologists Press, Palo Alto1976
- Structured Clinical Interview for DSM-IV Axis II Disorders—Patient Edition. Biometrics Research Dept, New York State Psychiatric Institute, New York1995
- Structured Clinical Interview for DSM-IV Axis I Disorders—Patient Edition. Biometrics Research Dept, New York State Psychiatric Institute, New York1995
- Neural correlates of internally-generated disgust via autobiographical recall: a functional magnetic resonance imaging investigation.Neurosci Lett. 2004; 370: 91-96
- The Obsessive-Compulsive Inventory: development and validation of a short version.Psychol Assess. 2002; 14: 485-496
- Neuroimaging studies of obsessive-compulsive disorder in adults and children.Clin Psychol Rev. 2006; 26: 32-49
- The Yale-Brown Obsessive Compulsive Scale (Y-BOCS), part I: development, use and reliability.Arch Gen Psychiatry. 1989; 46: 1006-1011
- Individual differences in sensitivity to disgust: A scale sampling seven domains of disgust elicitors.Pers Indiv Diff. 1994; 16: 701-713
- Task instructions modulate neural responses to fearful facial expressions.Biol Psychiatry. 2003; 53: 226-232
- The connection between disgust and obsessions and compulsions in a non-clinical sample.Pers Indiv Diff. 2001; 31: 1173-1180
- Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder.Arch Gen Psychiatry. 2004; 61: 564-576
- Disgust has arrived.J Anxiety Disord. 2002; 16: 561-566
- Functional MRI of the human amygdala?.Neuroimage. 2001; 14: 253-257
- Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder.J Neuropsychiatry Clin Neurosci. 1989; 1: 27-36
- A differential neural response in the human amygdala to fearful and happy facial expressions.Nature. 1996; 383: 812-815
- A neuromodulatory role for the human amygdala in processing emotional facial expressions.Brain. 1998; 121: 47-57
- Brain magnetic resonance imaging with contrast dependent blood oxygenation.Proc Natl Acad Sci USA. 1990; 87: 8868-8872
- The structure of disgust: domain specificity in relation to contamination ideation and excessive washing.Behav Res Ther. 2005; 43: 1069-1086
- No disgust recognition deficit in obsessive-compulsive disorder.J Behav Ther Exp Psychiatry. 2004; 35: 183-192
- Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI.Neuroimage. 2002; 16: 331-348
- A specific neural substrate for perception of facial expressions of disgust.Nature. 1997; 389: 495-498
- Disgust—the forgotten emotion of psychiatry.Br J Psychiatry. 1998; 172: 373-375
- Neural responses to facial and vocal expressions of fear and disgust.Proc R Soc Lond B. 1998; 265: 1809-1817
- A differential neural response in obsessive-compulsive patients with washing compared with checking symptoms to disgust.Psychol Medicine. 2000; 30: 1037-1050
- Neurobiology of emotion perception I: The neural basis of normal emotion perception.Biol Psychiatry. 2003; 54: 504-514
- Differential neural responses to overt and covert presentations of facial expressions of fear and disgust.Neuroimage. 2004; 21: 1484-1496
- Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder.Br J Psychiatry. 1998; 173: 26-38
- Neural responses of OCD patients towards disorder-relevant, generally disgust-inducing and fear-inducing pictures.Int J Psychophysiol. 2005; 57: 69-77
- Brain activation by disgust-inducing pictures in obsessive-compulsive disorder.Biol Psychiatry. 2003; 54: 751-756
- Quality control for functional magnetic resonance imaging using automated data analysis and Thwart charting.Magn Reson Med. 1999; 41: 1927-1931
- Manual for the State-Trait Anxiety Inventory (STAI). Consulting Psychologists Press, Palo Alto1983
- Neural structures associated with recognition of facial expressions of basic emotions.Proc Biol Sci. 1998; 265: 1927-1931
- The psychobiology of obsessive-compulsive disorder: how important is the role of disgust?.Curr Psychiatry Rep. 2001; 3: 281-287
- A preferential increase in the extrastriate response to signals of danger.Neuroimage. 2003; 19: 1317-1328
- Co-planar Stereotactic Atlas of the Human Brain. Thieme, Stuttgart, Germany1988
- Sympathetic magic in contamination-related OCD.J Behav Ther Exp Psychiatry. 2004; 35: 193-205
- Short Recognition Memory Test for Faces. Psychology Press, Hove, UK1996
- The relationship between disgust sensitivity and avoidant behavior: studies of clinical and nonclinical samples.J Anxiety Disord. 2002; 16: 543-559
- Facial expression megamix: Tests of dimensional and category accounts of emotion recognition.Cognition. 1997; 63: 271-313
Article info
Publication history
Published online: November 13, 2006
Accepted:
June 8,
2006
Received in revised form:
April 28,
2006
Received:
December 21,
2005
Identification
Copyright
© 2007 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.