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Misunderstandings About How to Choose a Reference Region

Published:September 21, 2006DOI:https://doi.org/10.1016/j.biopsych.2006.06.007
      In the recent article by
      • Parsey R.V.
      • Kent J.M.
      • Oquendo M.A.
      • Richards M.C.
      • Pratap M.
      • Cooper T.B.
      • et al.
      Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomography.
      , entitled, “Acute Occupancy of Brain Serotonin Transporter by Sertraline as Measured by [11C]DASB and Positron Emission Tomography,” there was an important error in the description of our method of reference region selection for our [11C]DASB positron emission tomography (PET) occupancy studies (
      • Meyer J.H.
      • Wilson A.A.
      • Ginovart N.
      • Goulding V.
      • Hussay D.
      • Hood K.
      • et al.
      Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: A [11C]DASB PET imaging study.
      ,
      • Meyer J.H.
      • Wilson A.A.
      • Sandra S.
      • Hussay D.
      • Carella A.
      • Potter Z.W.
      • et al.
      Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: An [11C] DASB positron emission tomography study.
      ). These original [11C]DASB PET occupancy studies assessed serotonin transporter (5-HTT) occupancy at many different doses for five different selective serotonin reuptake inhibitors (enrolling 77 subjects). As these original studies are being used as a standard reference for future antidepressant development, we felt it was important that our technique be described correctly.
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        Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: A [11C]DASB PET imaging study.
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        Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: An [11C] DASB positron emission tomography study.
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        Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomography.
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