Advertisement
Biological Psychiatry
Advanced SearchSave search
Correspondence| Volume 61, ISSUE 11, P1314, June 01, 2007

Misunderstandings About How to Choose a Reference Region

Published:September 21, 2006DOI:https://doi.org/10.1016/j.biopsych.2006.06.007
Misunderstandings About How to Choose a Reference Region
Previous ArticleDopamine β-Hydroxylase Gene (DβH) -1021C→T Influences Self-Reported Paranoia during Cocaine Self-Administration
Next ArticleReply
      In the recent article by
      • Parsey R.V.
      • Kent J.M.
      • Oquendo M.A.
      • Richards M.C.
      • Pratap M.
      • Cooper T.B.
      • et al.
      Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomography.
      Biol Psychiatry. 2006; 59: 821-828
      , entitled, “Acute Occupancy of Brain Serotonin Transporter by Sertraline as Measured by [11C]DASB and Positron Emission Tomography,” there was an important error in the description of our method of reference region selection for our [11C]DASB positron emission tomography (PET) occupancy studies (
      • Meyer J.H.
      • Wilson A.A.
      • Ginovart N.
      • Goulding V.
      • Hussay D.
      • Hood K.
      • et al.
      Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: A [11C]DASB PET imaging study.
      Am J Psychiatry. 2001; 158: 1843-1849
      ,
      • Meyer J.H.
      • Wilson A.A.
      • Sandra S.
      • Hussay D.
      • Carella A.
      • Potter Z.W.
      • et al.
      Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: An [11C] DASB positron emission tomography study.
      Am J Psychiatry. 2004; 161: 826-835
      ). These original [11C]DASB PET occupancy studies assessed serotonin transporter (5-HTT) occupancy at many different doses for five different selective serotonin reuptake inhibitors (enrolling 77 subjects). As these original studies are being used as a standard reference for future antidepressant development, we felt it was important that our technique be described correctly.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Ginovart N.
        • Wilson A.A.
        • Meyer J.H.
        • Hussay D.
        • Houle S.
        Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: Modeling strategies.
        J Cereb Blood Flow Metab. 2001; 21: 1342-1353
        View in Article
        • Kish S.J.
        • Furukawa Y.
        • Chang L.-J.
        • Ginovart N.
        • Wilson A.A.
        • Houle S.
        • et al.
        Regional distribution of serotonin transporter (SERT) protein in post mortem human brain: Is the cerebellum a SERT-free brain region?.
        Nucl Med Biol. 2005; 32: 123-128
        View in Article
        • Meyer J.H.
        • Wilson A.A.
        • Ginovart N.
        • Goulding V.
        • Hussay D.
        • Hood K.
        • et al.
        Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: A [11C]DASB PET imaging study.
        Am J Psychiatry. 2001; 158: 1843-1849
        View in Article
        • Meyer J.H.
        • Wilson A.A.
        • Sandra S.
        • Hussay D.
        • Carella A.
        • Potter Z.W.
        • et al.
        Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: An [11C] DASB positron emission tomography study.
        Am J Psychiatry. 2004; 161: 826-835
        View in Article
        • Parsey R.V.
        • Kent J.M.
        • Oquendo M.A.
        • Richards M.C.
        • Pratap M.
        • Cooper T.B.
        • et al.
        Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomography.
        Biol Psychiatry. 2006; 59: 821-828
        View in Article

      Article Info

      Publication History

      Published online: September 21, 2006

      Identification

      DOI: https://doi.org/10.1016/j.biopsych.2006.06.007

      Copyright

      © 2007 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2022 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX