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Correspondence| Volume 61, ISSUE 11, P1314, June 01, 2007

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Misunderstandings About How to Choose a Reference Region

Published:September 21, 2006DOI:https://doi.org/10.1016/j.biopsych.2006.06.007
Misunderstandings About How to Choose a Reference Region
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      In the recent article by
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      Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomography.
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      , entitled, “Acute Occupancy of Brain Serotonin Transporter by Sertraline as Measured by [11C]DASB and Positron Emission Tomography,” there was an important error in the description of our method of reference region selection for our [11C]DASB positron emission tomography (PET) occupancy studies (
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      • Wilson A.A.
      • Ginovart N.
      • Goulding V.
      • Hussay D.
      • Hood K.
      • et al.
      Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: A [11C]DASB PET imaging study.
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      • Wilson A.A.
      • Sandra S.
      • Hussay D.
      • Carella A.
      • Potter Z.W.
      • et al.
      Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: An [11C] DASB positron emission tomography study.
      Am J Psychiatry. 2004; 161: 826-835
      ). These original [11C]DASB PET occupancy studies assessed serotonin transporter (5-HTT) occupancy at many different doses for five different selective serotonin reuptake inhibitors (enrolling 77 subjects). As these original studies are being used as a standard reference for future antidepressant development, we felt it was important that our technique be described correctly.
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      References

        • Ginovart N.
        • Wilson A.A.
        • Meyer J.H.
        • Hussay D.
        • Houle S.
        Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: Modeling strategies.
        J Cereb Blood Flow Metab. 2001; 21: 1342-1353
        View in Article
        • Kish S.J.
        • Furukawa Y.
        • Chang L.-J.
        • Ginovart N.
        • Wilson A.A.
        • Houle S.
        • et al.
        Regional distribution of serotonin transporter (SERT) protein in post mortem human brain: Is the cerebellum a SERT-free brain region?.
        Nucl Med Biol. 2005; 32: 123-128
        View in Article
        • Meyer J.H.
        • Wilson A.A.
        • Ginovart N.
        • Goulding V.
        • Hussay D.
        • Hood K.
        • et al.
        Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: A [11C]DASB PET imaging study.
        Am J Psychiatry. 2001; 158: 1843-1849
        View in Article
        • Meyer J.H.
        • Wilson A.A.
        • Sandra S.
        • Hussay D.
        • Carella A.
        • Potter Z.W.
        • et al.
        Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: An [11C] DASB positron emission tomography study.
        Am J Psychiatry. 2004; 161: 826-835
        View in Article
        • Parsey R.V.
        • Kent J.M.
        • Oquendo M.A.
        • Richards M.C.
        • Pratap M.
        • Cooper T.B.
        • et al.
        Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomography.
        Biol Psychiatry. 2006; 59: 821-828
        View in Article

      Article info

      Publication history

      Published online: September 21, 2006

      Identification

      DOI: https://doi.org/10.1016/j.biopsych.2006.06.007

      Copyright

      © 2007 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

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