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Regarding “Increased Prefrontal and Hippocampal Glutamate Concentration in Schizophrenia: Evidence from a Magnetic Resonance Spectroscopy Study”

Published:September 04, 2006DOI:https://doi.org/10.1016/j.biopsych.2006.05.037
      As schizophrenia researchers specializing in the use of brain MRS, we present our shared concerns regarding the results of van Elst et al. (2005) published in Biological Psychiatry. This study of chronic schizophrenia and healthy controls used standard single-voxel 1H-MRS methodology to acquire and process spectroscopy from the dorsolateral prefrontal (DLPC) and hippocampal areas. We question the variability and accuracy of the metabolite concentrations presented in this paper.

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