Background
Insulin has emerged as an important determinant of food intake, energy expenditure,
and weight control. This study examined the relationship between fasting serum insulin
level and resting energy expenditure (REE) in a cross-sectional sample of nondiabetic
schizophrenia patients.
Methods
Subjects were recruited from an urban community mental health clinic. Each subject
underwent a series of anthropometric measures and an indirect calorimetry measure.
A fasting blood sample was taken for plasma glucose, serum insulin, and lipid profile.
Results
Seventy-one subjects (54 male, 17 female) were included in the study. There was a
significant positive relationship between REE and fasting serum insulin level (r = .39, p = .001). Stepwise multiple regression analysis was performed with various characteristics
such as age, race, antipsychotic agent used, fat-free mass, BMI, waist circumference,
waist–hip ratio, physical activity level, and fasting serum insulin as candidate predictors
for REE. Only fat-free mass and insulin were able to enter into the regression model,
which indicates that higher fat-free mass and higher fasting serum insulin level predict
increased REE.
Conclusions
A higher fasting serum insulin level is associated with an increased REE, which may
prevent further weight gain in nondiabetic patients with schizophrenia.
Key Words
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Article info
Publication history
Published online: August 21, 2006
Accepted:
May 10,
2006
Received in revised form:
April 10,
2006
Received:
January 20,
2006
Identification
Copyright
© 2006 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
