Background
Growing evidence indicates that the entorhinal cortex (ECx) might be affected in schizophrenia
(SZ) and bipolar disorder (BD). To test whether distinct interneuronal subpopulations
might be altered, numbers of parvalbumin-immunoreactive (PVB-IR) neurons were measured
in the ECx of BD and SZ subjects. These neurons play a pivotal role within ECx intrinsic
circuits.
Methods
Numbers, numerical density, and soma size of PVB-IR neurons were measured in the ECx
of normal control (n = 16), BD (n = 10), and SZ (n = 10) subjects. The volume of the ECx was measured in Nissl-stained sections.
Results
In BD, decreases of total numbers (p = .02) and numerical densities (p = .01) of PVB-IR neurons were detected in the ECx. Within distinct subregions, reductions
were detected in the superficial layers of the lateral (p = .02), intermediate (p = .04), and caudal (p = .01) ECx. In SZ, total numbers and numerical densities were not altered. A reduction
of soma size was present in the intermediate ECx (p = .01). Volume was unaffected in either disorder.
Conclusions
In BD, a decrease of PVB-IR neurons may alter intrinsic inhibitory networks within
the superficial layers of the ECx. The likely consequence is a disruption of integration
and transfer of information from the cerebral cortex to the hippocampus.
Key Words
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Article info
Publication history
Published online: September 04, 2006
Accepted:
April 27,
2006
Received in revised form:
April 26,
2006
Received:
March 13,
2006
Identification
Copyright
© 2007 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
