Background
The disruption of the disrupted-in-schizophrenia (DISC1) gene segregates with major
mental illnesses in a Scottish family. Association of DISC1 with schizophrenia has
been reported in several ethnic groups, and now recently with mood disorder.
Methods
A family-based association study of DISC1 and bipolar disorder (BP) in 57 bipolar
pedigrees was conducted. Then, we examined possible association of bipolar disorder
with DISC1 mRNA expression in human lymphoblasts. We also studied the correlation
of several clinical features with the levels of DISC1 mRNA expression.
Results
Haplotype analysis identified one haplotype (HP1) that was overtransmitted to the
BP phenotype (p = .01) and a second haplotype that was undertransmitted (HP2). There was a gender
influence in the transmission distortion, with overtransmission of HP1 to affected
females (p = .004). A significant decrease in DISC1 mRNA expression was observed in lymphoblasts
from affected HP1 group compared to those from unaffected subjects with the HP2 (p = .006). Further, a higher number of manic symptoms correlated with lower levels
of DISC1 expression (p = .008).
Conclusions
These results suggest that decreased mRNA levels of DISC1 expression, associating
with the risk haplotype, may be implicated in the pathophysiology of bipolar disorder.
Key Words
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Article info
Publication history
Published online: June 29, 2006
Accepted:
March 23,
2006
Received in revised form:
July 28,
2005
Received:
January 26,
2005
Identification
Copyright
© 2006 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
