Original article| Volume 60, ISSUE 7, P677-683, October 01, 2006

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Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype


      A functional promoter polymorphism in monoamine oxidase A (MAOA) has been implicated as a moderating factor in the relationship between childhood maltreatment and later adolescent and adult antisocial behavior. Despite wide interest in this hypothesis, results remain mixed from the few attempts at replication.


      Regression-based analyses were conducted to test for a genotype-environment interaction using self-reported physical abuse and MAOA genotype to predict later antisocial behavior and arrests for violence by participants in the National Youth Survey Family Study. We also examined the interaction using a measure of violent victimization. The analysis sample included 277 Caucasian male respondents, aged 11–15 in 1976, who provided buccal swab DNA samples and who were successfully genotyped for the variable number tandem repeat (VNTR) in the MAOA promoter using polymerase chain reaction.


      Maltreatment by a parent during adolescence was a risk factor for adolescent and adult antisocial and violence related behavioral problems. Tests for the main effect of MAOA and a MAOA-maltreatment interaction were nonsignificant. Similar results were obtained using the measure of adolescent violent victimization.


      Findings from this general population sample could not confirm the hypothesis that MAOA moderates the relationship between adolescent maltreatment and adolescent or adult antisocial behavior.

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        • Anchordoquy H.C.
        • McGeary C.
        • Liu L.
        • Krauter K.S.
        • Smolen A.
        Genotyping of Three Candidate Genes After Whole-Genome Preamplification of DNA Collected from Buccal Cells.
        Behav Genet. 2003; 33: 73-78
        • Boney-McCoy S.
        • Finkelhor D.
        Psychosocial sequelae of violent victimization in a National Youth Sample.
        J Consult Clin Psychology. 1995; 63: 726-736
        • Brunner H.G.
        • Nelen M.
        • Breakfield X.O.
        • Ropers H.H.
        • Van Oost B.A.
        Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A.
        Science. 1993; 262: 578-580
        • Cases O.
        • Seif I.
        • Grimsby J.
        • Gaspar P.
        • Chen K.
        • Pournin S.
        • et al.
        Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.
        Science. 1995; 268: 1763-1766
        • Caspi A.
        • McClay J.
        • Moffitt T.E.
        • Mill J.
        • Martin J.
        • Craig I.W.
        • et al.
        Role of genotype in the cycle of violence in maltreated children.
        Science. 2002; 297: 851-854
        • De Bellis M.D.
        Developmental traumatology: The psychobiological development of maltreated children and its implication for research, treatment, and policy.
        Dev Psychopathol. 2001; 13: 539-564
        • Deckert J.
        • Catalano M.
        • Syagailo Y.V.
        • Bosi M.
        • Okladnova O.
        • Di Bella D.
        • et al.
        Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder.
        Hum Mol Genet. 1999; 8: 621-624
        • Denney R.M.
        • Koch H.
        • Craig I.W.
        Association between monoamine oxidase A activity in human male skin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat.
        Hum Genet. 1999; 105: 542-551
        • Don R.H.
        • Cox P.T.
        • Wainwright B.J.
        • Baker K.
        • Mattick J.S.
        “Touchdown” PCR to circumvent spurious priming during gene amplification.
        Nucleic Acids Res. 1991; 19: 4008
        • Elliott D.S.
        • Huizinga D.
        • Menard S.
        Multiple Problem Youth: Delinquency, Drugs and Mental Health. Springer-Verlag, New York1989
        • Epstein S.
        The stability of behavior: I. On predicting most of the people much of the time.
        J Personality Soc Psych. 1979; 37: 1097-1127
        • Fagan A.A.
        The short- and long-term effects of violent victimization experienced within the family and community.
        Violence Vict. 2003; 18: 445-459
        • Foley D.L.
        • Eaves L.J.
        • Wormley B.
        • Silberg J.
        • Maes H.H.
        • Kuln
        • et al.
        Childhood adversity, monoamine oxidase A genotype, and risk for conduct disorder.
        Arch Gen Psychiatry. 2004; 61: 738-744
        • Glaser D.
        Child abuse and neglect and the brain – a review.
        J Child Psychology Psychiatry. 2001; 41: 97-116
        • Haberstick B.C.
        • Lessem J.M.
        • Hopfer C.J.
        • Smolen A.
        • Timberlake D.
        • Hewitt J.K.
        Monoamine oxidase A (MAOA) and antisocial behaviors in childhood and adolescent maltreatment.
        Am J Med Genet. 2005; 135B: 59-64
        • Ireland T.O.
        • Smith C.
        • Thornberry T.P.
        Developmental issues in the impact of child maltreatment on later delinquency and drug use.
        Criminology. 2002; 40: 359-399
        • Kochersperger L.M.
        • Parker E.L.
        • Siciliano M.
        • Darlington G.J.
        • Denney R.M.
        Assignment of genes for human monoamine oxidase A and B to the X chromosome.
        J Neurosci Res. 1986; 16: 601-616
        • Lan N.C.
        • Heinzman C.
        • Gal A.
        • Klisak I.
        • Orth U.
        • Lai E.
        • et al.
        Human monoamine oxidase A and B map to Xp11.23 and are deleted in patient with Norrie disease.
        Genomics. 1989; 4: 552-559
        • Malinosky-Fummerll R.
        • Hansen D.J.
        Long-term consequences of childhood physical abuse.
        Psychol Bull. 1993; 114: 68-79
        • Mejia J.M.
        • Ervin F.R.
        • Baker G.B.
        • Palmour R.M.
        Monoamine oxidase inhibition during brain development induces pathological aggressive behavior in mice.
        Biol Psychiatry. 2002; 52: 811-822
        • Menard S.
        Longitudinal Research. Second Addition. Sage, Thousand Oaks, CA2002
        • Ozelius L.
        • Hsu Y.P.
        • Bruns G.
        • Powell J.F.
        • Chen S.
        • Weyler W.
        • et al.
        Human monoamine oxidase gene (MAOA): chromosome position (Xp21-Xp11) and DNA polymorphism.
        Genomics. 1988; 3: 53-58
        • Pintar J.E.
        • Barbosa J.
        • Francke U.
        • Castiglione C.M.
        • Hawking M.
        • Breakefield X.O.
        Gene for monoamine oxidase A assigned to human X chromosome.
        J Neurosci. 1981; 1: 166-175
        • Sabol S.Z.
        • Hu S.
        • Hamer D.
        A functional polymorphism in the monoamine oxidase A gene promoter.
        Hum Genet. 1998; 103: 273-279
        • Sanchez M.M.
        • Ladd C.O.
        • Plotsky P.M.
        Early adverse experience as a developmental risk factor for later psychopathology: Evidence from rodent and primate models.
        Dev Psychopathol. 2001; 13: 419-449
        • Stevenson J.
        The treatment of the long-term sequelae of child abuse.
        J Child Adolesc Psychiatry. 1999; 40: 89-111
        • Teicher M.H.
        • Andersen S.L.
        • Polcari A.
        • Anderson C.M.
        • Navalta C.P.
        • Kim D.M.
        The neurobiological consequences of early stress and childhood maltreatment.
        Neurosci Biobehav Rev. 2001; 27: 33-44
        • Thornberrry T.P.
        • Ireland T.O.
        • Smith C.A.
        The importance of timing: The varying impact of childhood and adolescent maltreatment on multiple problem outcomes.
        Dev Psychopathol. 2001; 13: 957-979
        • Young S.E.
        • Smolen A.
        • Hewitt J.K.
        • Haberstick B.C.
        • Stallings M.C.
        • Corley R.P.
        • Crowley T.J.
        Clinical validation of possible links between MAO-A genotype and maltreatment in the risk for adolescent conduct disorder.
        Am J Psychiatry. 2006; 163: 1-7