Background
Weight gain and type 2 diabetes mellitus (DM) are often linked to antipsychotics treatment.
The aim of the study is to investigate serum free fatty acids (FFA) levels in schizophrenic
patients who received long-term antipsychotics treatment, and to explore the associations
between serum FFA and fasting blood glucose, and insulin resistance.
Methods
308 inpatients with schizophrenia who met with the criteria of DSM-IV were recruited
into this study, and were divided into four groups: control subjects, single obesity,
impaired glucose tolerance (IGT) and type 2 DM according to different body mass index,
fasting blood glucose level and 2-hour postprandial blood glucose. Serum FFA was measured
with colorimetry. Serum insulin and leptin were measured with radioimmunoassay respectively.
Results
There was a significant elevation in serum FFA levels in schizophrenic patients who
received long-term antipsychotics treatment, especially in single obesity, IGT, and
DM groups. The elevated serum FFA was remarkably positive correlated with fasting
blood glucose and insulin resistance.
Conclusions
The study suggested the elevated serum FFA in schizophrenic patients with long-term
antipsychotics treatment affected the blood glucose metabolism, may have played an
important role in insulin resistance and type 2 DM, and was also an important trait
of metabolic syndromes.
Key Words
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Article info
Publication history
Published online: May 02, 2006
Accepted:
March 3,
2006
Received in revised form:
February 28,
2006
Received:
June 14,
2005
Identification
Copyright
© 2006 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
