Background
While light has proven an effective treatment for Seasonal Affective Disorder (SAD),
an optimal wavelength combination has not been determined. Short wavelength light
(blue) has demonstrated potency as a stimulus for acute melatonin suppression and
circadian phase shifting.
Methods
This study tested the efficacy of short wavelength light therapy for SAD. Blue light
emitting diode (LED) units produced 468 nm light at 607 μW/cm2 (27 nm half-peak bandwidth); dim red LED units provided 654 nm at 34 μW/cm2 (21 nm half-peak bandwidth). Patients with major depression with a seasonal pattern,
a score of ≥20 on the Structured Interview Guide for the Hamilton Depression Rating
Scale-SAD version (SIGH-SAD) and normal sleeping patterns (routine bedtimes between
10:00 pm and midnight) received 45 minutes of morning light treatment daily for 3
weeks. Twenty-four patients completed treatment following random assignment of condition
(blue vs. red light). The SIGH-SAD was administered weekly.
Results
Mixed-effects analyses of covariance determined that the short wavelength light treatment
decreased SIGH-SAD scores significantly more than the dimmer red light condition (F = 6.45, p = .019 for average over the post-treatment times).
Conclusions
Narrow bandwidth blue light at 607 μW/cm2 outperforms dimmer red light in reversing symptoms of major depression with a seasonal
pattern.
Key Words
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References
- Documentation of the Threshold Limit Values and Biological Exposure Indices. American Conference of Governmental Industrial Hygienists, Cincinnati, Ohio2003
- Recommended Practice for Photobiological Safety for Lamps and Lamp Systems- General Requirements. Illuminating Engineering Society of North America, New York, New York1996 (RP 27.1.)
- Phototherapy with broad spectrum white fluorescent light.Psychiatry Res. 1992; 43: 167-175
- Transmission of the ocular media.Invest Ophthalmol Vis Sci. 1962; 1: 776-783
- The healing light.in: Lam R.W. Seasonal Affective Disorder and Beyond Light Treatment for SAD and NonSAD Conditions. American Psychiatric Press, Inc, Washington, D.C1998: 1-44
- Action spectrum for melatonin regulation in humans.J Neurosci. 2001; 21: 6405-6412
- Human melatonin regulation is not mediated by the three cone photopic visual system.J Clin Endocrinol Metab. 2001; 86: 433-436
- Effects of different wavelengths in seasonal affective disorder.J Affective Disord. 1990; 20: 209-216
- Action spectrum of the retinal mechanism mediating nocturnal light-induced suppression of rat pineal gland N-acetyltransferase.Brain Res. 1987; 406: 352-356
- In pursuit of the ultimate lamp.Sci Am. 2001; 284: 62-67
- Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle.Science. 1986; 233: 667-671
- Is seasonal affective disorder a disorder of circadian rhythms?.CNS Spectrums. 2001; 6: 487-501
- Bright light treatment of winter depression.Arch Gen Psychiatry. 1998; 55: 883-889
- Structured Clinical Interview for DSM-IV-TR Axis I Disorders - Patient Edition. New York Psychiatric Institute, New York2001
- Light-induced melatonin suppression in healthy humans with narrow-band light-emitting diodes.Chronobiol Int. 2003; 20: 1181-1183
- Rhodopsin mediated blue light damage to the rat retina.Invest Ophthalmol Vis Sci. 2001; 42: 497-505
- The intraocular straylight function in 129 healthy volunteers; dependence on angle, age and pigmentation.Vision Res. 1990; 30: 699-707
- Guidelines on limits of exposure to broad-band incoherent optical radiation (0.38 to 3 microM).Health Phys. 1997; 73: 539-554
- Side effects of short-term 10,000-lux light therapy.Am J Psychiatry. 1998; 155: 293-294
- Side effects induced by bright light treatment for seasonal affective disorder.J Clin Psychiatry. 1994; 55: 189-191
- Seasonal Affective Disorder.Prim Care Psychiatry. 1998; 4: 63-74
- Ultraviolet versus nonultraviolet light therapy for Seasonal Affective Disorder.J Clin Psychiatry. 1991; 52: 213-216
- Spectral properties of phototherapy for seasonal affective disorder.Acta Psychiatr Scand. 1997; 96: 117-121
- Morning vs evening light treatment of patients with winter depression.Arch Gen Psychiatry. 1998; 55: 890-896
- Bright artificial light treatment of a manic-depressive patient with a seasonal mood cycle.Am J Psychiatry. 1982; 139: 1496-1498
- Antidepressant and circadian phase-shifting effects of light.Science. 1987; 235: 352-354
- Light suppresses melatonin secretion in humans.Science. 1980; 210: 1267-1269
- High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light.J Clin Endocrinol Metab. 2003; 88: 4502-4505
- Treatment of seasonal affective disorder with green light versus red light.Am J Psychiatry. 1991; 148: 509-511
- Seasonal affective disorders.in: Paykel E.S. Handbook of Affective Disorders. Churchill Livingstone, London1992: 551-567
- Lighting Handbook. Illuminating Engineering Society of North America, New York2000
- Bright light therapy in focus.Technol Health Care. 1996; 4: 403-413
- Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy.Arch Gen Psychiatry. 1984; 41: 72-80
- Effects of green or white light for treatment of seasonal depression.Psychiatry Res. 1991; 38: 261-270
- Circadian time of morning light administration and therapeutic response in winter depression.Arch Gen Psychiatry. 2001; 58: 69-75
- Bright light therapy.J Clin Psychiatry. 1999; 60: 799-808
- A controlled trial of timed bright light and negative air ionization for treatment of winter depression.Arch Gen Psychiatry. 1998; 55: 875-882
- An action spectrum for melatonin suppression.J Physiol. 2001; 535: 261-267
- Retinopathy and bright light therapy.Am J Psychiatry. 1992; 149 ([letter]): 1610-1611
- A circadian signal of change of season in patients with seasonal affective disorder.Arch Gen Psychiatry. 2001; 58: 1108-1114
- Conservation of photoperiod-responsive mechanisms in humans.Am J Physiol. 1993; 265: R846-R857
- Light therapy for Seasonal Affective Disorder.in: Lam R.W. Seasonal Affective Disorder and Beyond Light Treatment for SAD and NonSAD Conditions. American Psychiatric Press, Washington, D.C1998: 45-89
- Structured Interview Guide for the Hamilton Depression Rating Scale - Seasonal Affective Disorder Version (SIGH-SAD). New York Psychiatric Institute, New York1994
- Psychophysical determination of intraocular light scatter as a function of wavelength.Vision Res. 1987; 27: 1291-1298
- Differential effects of light wavelength in phase advancing the melatonin rhythm.J Pineal Res. 2004; 36: 140-144
Article Info
Publication History
Published online: September 14, 2005
Accepted:
July 1,
2005
Received in revised form:
June 8,
2005
Received:
December 9,
2004
Identification
Copyright
© 2005 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
