Abnormalities in perception and evaluation of body shape are a hallmark of eating disorders.
Brain responses to line drawings of underweight, normal weight, and overweight female bodies were measured with functional magnetic resonance imaging in 9 women with bulimia nervosa, 13 with anorexia nervosa, and 18 healthy women. Participants rated the stimuli for fear and disgust.
In the three groups, the lateral fusiform gyrus, inferior parietal cortex, and lateral prefrontal cortex were activated in response to body shapes compared with the control condition (drawings of houses). The responses in the lateral fusiform gyrus and in the parietal cortex were less strong in patients with eating disorders compared with healthy control subjects. Patients with eating disorders rated the body shapes in all weight categories as more aversive than did healthy women. In the group with eating disorders, the aversion ratings correlated positively with activity in the right medial apical prefrontal cortex.
Processing of female body shapes engages a distributed neural network, parts of which are underactive in women with eating disorders. The considerable variability in subjective emotional reaction to body shapes in patients with eating disorders is associated with differential activity in the prefrontal cortex.
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- American Psychiatric Press, Washington, DC1994 Diagnostic and Statistical Manual for Mental Disorders. 4th ed.
- Relating body mass index to figural stimuli.Int J Obes. 2001; 25: 1517-1524
- Methods for diagnosis and treatment of stimulus-correlated motion in generic brain activation studies using fMRI.Hum Brain Mapp. 1999; 7: 38-48
- Global, voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain.IEEE Trans Med Imaging. 1999; 18: 32-42
- Relapse in anorexia nervosa.Psychol Med. 2004; 34: 671-679
- The nature and extent of body-image disturbances in anorexia nervosa and bulimia nervosa.Int J Eat Disord. 1997; 22: 107-125
- A three-year longitudinal study of body image and eating disturbance in adolescent females.Eat Disord J Treat Prevention. 1994; 2: 114-125
- Attribute-based neural substrates in temporal cortex for perceiving and knowing about objects.Nat Neurosci. 1999; 2: 913-919
- A cortical area selective for visual processing of the human body.Science. 2001; 293: 2470-2473
- Functional anatomy of calorie fear in anorexia nervosa.Lancet. 1998; 352: 1192
- The Eating Disorders Examination.in: Fairburn C.G. Wilson G.T. Binge Eating Nature, Assessment & Treatment. 12th ed. Guilford Press, New York1993
- Predictors of 12-month outcome in bulimia nervosa and the influence of attitudes to shape and weight.J Consult Clin Psychol. 1993; 61: 696-698
- Sex differences in perceptions of desirable body shape.J Abnorm Psychol. 1985; 94: 102-105
- The effect of experimental presentation of thin media images on body satisfaction.Int J Eat Disord. 2002; 31: 1-16
- Deficits in haptic perception and right parietal theta power changes in patients with anorexia nervosa before and after weight gain.Int J Eat Disord. 2001; 29: 417-428
- Relapse predictors of patients with bulimia nervosa who achieved abstinence through cognitive behavioral therapy.Arch Gen Psychiatry. 2002; 59: 1105-1109
- Distributed representation of objects in the human ventral visual pathway.Proc Natl Acad Sci U S A. 1999; 96: 9379-9384
- Weight concerns influence the development of eating disorders.J Consult Clin Psychol. 1996; 64: 936-940
- Unawareness of deficits in neuropsychological syndromes.J Clin Exp Neuropsychol. 1989; 11: 143-205
- Functional neuroanatomy of emotions.Cogn Affect Behav Neurosci. 2003; 3: 207-233
- Hype and weight.Med Anthropol. 1991; 13: 249-284
- Functional neuroanatomy of emotion.Neuroimage. 2002; 16: 331-348
- Body experience in eating disorders before and after treatment.Eur Psychiatry. 1999; 14: 333-340
- Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations.Hum Mol Genet. 2004; 13: 1205-1212
- Women and weight.in: Sonderegger T.B. Psychology and Gender. University of Nebrasca Press, Lincoln1993: 267-307
- Body image distortion reveals amygdala activation in patients with anorexia nervosa—a functional magnetic resonance imaging study.Neurosci Lett. 2002; 326: 25-28
- Temporomesial activation in young females associated with unpleasant words concerning body image.Neuropsychobiology. 2003; 48: 136-142
- Hemispheric differences in body image in anorexia nervosa.Int J Eat Disord. 2001; 29: 409-416
- Adverse effects of social pressure to be thin on young women.Int J Eat Disord. 2003; 34: 108-117
- Role of body image dissatisfaction in the onset and maintenance of eating pathology.J Psychosom Res. 2002; 53: 985-993
- Co-planar stereotaxic atlas of the human brain. Thieme Medical, New York1988
- An examination of perceptual and cognitive set shifting tasks in acute anorexia nervosa and following recovery.Eat Weight Disord. 2002; 7: 312-315
- Exacting Beauty. American Psychological Association, Washington, DC1999
- Thin ideals in music television.Int J Eat Disord. 2004; 35: 48-58
- Recovery and chronicity in anorexia nervosa.Biol Psychiatry. 2003; 54: 934-942
- Medial prefrontal cortex activity associated with symptom provocation in eating disorders.Am J Psychiatry. 2004; 161: 1238-1246
- Neuronal activity changes and body image distortion in anorexia nervosa.Neuroreport. 2003; 14: 2193-2197
- Psychological versus pharmacological treatments of bulimia nervosa.J Consult Clin Psychol. 1999; 67: 451-459
Published online: August 08, 2005
Accepted: May 13, 2005
Received in revised form: May 11, 2005
Received: March 11, 2005
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