Background
The anxious phenotype of the 5-HT1A receptor knockout mouse and the anxiolytic properties of 5-HT1A agonists suggest that the 5-HT1A receptor modulates anxiety. We investigated the relationship of anxiety expressed
in major depressive disorder (MDD) to regional 5-HT1A binding.
Methods
Positron emission tomography with [carbonyl-11C]WAY-100635 was used to estimate regional 5-HT1A binding potential (BP) in 28 medication-free MDD subjects. Stepwise linear regression
assessed the predictive capacity of three anxiety components, derived from a larger
MDD sample and termed psychic, somatic, and motoric anxiety, on regional 5-HT1A BP.
Results
Higher psychic (β ≥ .63) and lower somatic (β ≤ –.70) anxiety predicted over 50% of
the variance in 5-HT1A BP in multiple cortical regions, but not in amygdala, hippocampus, or autoreceptors
of the raphe nuclei. The psychic and somatic anxiety components were not related to
depression severity. Comorbid panic disorder was associated with lower cortical and
subcortical 5-HT1A BP.
Conclusions
The 5-HT1A receptor in the same brain regions has different relationships to psychic anxiety
versus somatic anxiety. Lower 5-HT1A BP in panic disorder may be accounted for by higher somatic and lower psychic anxiety.
Further study of the pathobiology of these anxiety components may identify distinct
therapeutic targets or mechanisms.
Key Words
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Article info
Publication history
Published online: July 25, 2005
Accepted:
May 4,
2005
Received in revised form:
April 29,
2005
Received:
November 18,
2004
Identification
Copyright
© 2005 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
