The Genetics of Attention-Deficit/Hyperactivity Disorder

      Recent developments in molecular genetics have accelerated the search for susceptibility genes for attention-deficit/hyperactivity disorder (ADHD). In addition, several attempts have been made to better understand the inherited phenotypes of ADHD by examining neuropsychological constructs that may be related to the manifestation of the disorder. Papers in this section demonstrate that significant progress has been made over the last decade in understanding the genetics and phenotype of ADHD. This concluding commentary suggests additional approaches for future work.
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        • Alsobrook II, J.P.
        • Pauls D.L.
        A factor analysis of tic symptoms in Gilles de la Tourette syndrome.
        Am J Psychiatry. 2002; 159: 291-296
        • Altshuler J.S.
        • Altshuler D.
        Organizational challenges in clinical genomic research.
        Nature. 2004; 429: 478-481
        • Dorus S.
        • Vallender E.J.
        • Evans P.D.
        • Anderson J.R.
        • Gilbert S.L.
        • Mahowald M.
        • et al.
        Accelerated evolution of nervous system genes in the origin of Homo sapiens.
        Cell. 2004; 119: 1027-1040
        • Doyle A.E.
        • Willcutt E.G.
        • Seidman L.J.
        • Biederman J.
        • Chouinard V.-A.
        • Silva J.
        • Faraone S.V.
        Attention-deficit/hyperactivity disorder endophenotypes.
        Biol Psychiatry. 2005; 57: 1324-1335
        • Faraone S.V.
        • Perlis R.H.
        • Doyle A.E.
        • Smoller J.W.
        • Goralnick J.J.
        • Holmgren M.A.
        • Sklar P.
        Molecular Genetics of Attention-Deficit/Hyperactivity Disorder.
        Biol Psychiatry. 2005; 57: 1313-1323
        • Fisher S.E.
        • DeFries J.C.
        Developmental dyslexia.
        Nat Rev Neurosci. 2002; 3: 767-780
        • Gottesman I.I.
        • Gould T.D.
        The endophenotype concept in psychiatry.
        Am J Psychiatry. 2003; 160: 636-645
        • Kidd K.K.
        New genetic strategies for studying psychiatric disorders.
        in: Sakai T. Tsuboi T. Genetic Aspects of Human Behavior. Igaku-Shoin LTD, Tokyo, Japan1984: 325-346
        • Leckman J.F.
        • Pauls D.L.
        • Zhang H.
        • Rosario-Campos M.C.
        • Katsovich L.
        • Kidd K.K.
        • et al.
        Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome.
        Am J Med Genet. 2003; 116B: 60-68
        • Sebat J.
        • Lakshmi B.
        • Troge J.
        • Alexander J.
        • Young J.
        • Lundin P.
        • et al.
        Large-scale copy number polymorphism in the human genome.
        Science. 2004; 305: 525-528
        • Sklar P.
        Principles of haplotype mapping and potential application to attention-deficit/hyperactivity disorder.
        Biol Psychiatry. 2005; 57: 1357-1366
        • Todd R.D.
        • Rasmussen E.R.
        • Neuman R.J.
        • Reich W.
        • Hudziak J.J.
        • Bucholz K.K.
        • et al.
        Familiality and heritability of subtypes of attention deficit hyperactivity disorder in a population sample of adolescent female twins.
        Am J Psychiatry. 2001; 158: 1891-1898
        • Waldman I.D.
        Statistical approaches to complex phenotypes.
        Biol Psychiatry. 2005; 57: 1347-1356
        • Willcutt E.G.
        • Doyle A.E.
        • Nigg J.T.
        • Faraone S.V.
        • Pennington B.F.
        Validity of the executive function theory of attention-deficit/hyperactivity disorder.
        Biol Psychiatry. 2005; 57: 1336-1346