Background
The glutamatergic system, the major excitatory neurotransmitter system in the central
nervous system (CNS) has been proposed as contributing a possible role in the etiology
of attention deficit hyperactivity disorder (ADHD). This is based upon observations
from animal, neuroimaging, neuroanatomical and neuropsychological studies. Genes related
to glutamate function are therefore good functional candidates for this disorder.
The SLC1A3 (Solute Carrier Family 1, member 3) gene encodes a glial glutamate transporter
which maps to chromosome 5p12, a region of linkage that coincides in two published
ADHD genome scans so far. SLC1A3 is thus both a functional and positional candidate
gene for ADHD.
Methods
We have undertaken detailed association analysis of SLC1A3 using a multi-stage approach
for candidate gene analysis.
Results
In a family-based sample (n = 299) we found a significant association between marker rs2269272 (p = .007) and ADHD. Two, two-marker haplotypes, rs2269272/rs3776581 (p = .016) and rs2269272/rs2032893 (p = .013) also yielded evidence of association.
Conclusions
The results of our study suggest that genetic variation in SLC1A3 may contribute to
susceptibility to ADHD.
Key Words
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Article info
Publication history
Accepted:
March 14,
2005
Received in revised form:
February 22,
2005
Received:
November 24,
2004
Identification
Copyright
© 2005 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
