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Review| Volume 58, ISSUE 4, P265-271, August 15, 2005

Aging-Related Diagnostic Variations: Need for Diagnostic Criteria Appropriate for Elderly Psychiatric Patients

      It is commonly thought and taught that most psychiatric disorders other than dementia are much less prevalent among the elderly than among younger adults. This perception is based on a relatively small number of published epidemiologic investigations of the incidence and prevalence of mental illnesses in elderly populations. Most of these studies have had a number of methodologic problems, including improper definitions and diagnostic criteria for older persons. A likely consequence of these misconceptions is that clinically significant and potentially treatable mental illnesses might be overlooked, misdiagnosed, and mistreated in elderly patients. Studies in community samples suggest that many older adults who experience clinically significant psychopathology do not fit easily into our existing nomenclature, and yet are disabled. There is a need to develop aging-appropriate diagnostic criteria for major psychiatric disorders. In this article, we discuss the potential causes of this diagnostic confusion. Four specific classes of disorders—mood (specifically depressive) disorders, schizophrenia (and related psychotic disorders), anxiety disorders, and substance use disorders—are discussed as examples. Finally, we suggest some future steps for clarifying this diagnostic confusion.

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      References

        • Adams K.
        Depressive symptoms, depletion, or developmental change? Withdrawal, apathy, or lack of vigor in the Geriatric Depression Scale.
        The Gerontologist. 2001; 41: 768-777
        • Alexopoulos G.S.
        • Meyers B.S.
        • Young R.C.
        • Campbell S.
        • Silbersweig D.
        • Charleson M.
        ‘Vascular depression’ hypothesis.
        Arch Gen Psychiatry. 1997; 54: 915-922
        • Alexopoulos G.S.
        • Vrontou C.
        • Kakuma T.
        • Meyers B.S.
        • Young R.C.
        • Klausner E.
        • et al.
        Disability in geriatric depression.
        Am J Psychiatry. 1996; 153: 877-885
        • American Psychiatric Association
        Diagnostic and Statistical Manual of Mental Disorders. 4th ed. American Psychiatric Association, Washington, DC1994
        • Beats B.
        • Sahakian B.
        • Levy R.
        Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed.
        Psychol Med. 1996; 26: 591-603
        • Beekman A.T.
        • Deeg D.J.
        • van Tilburg T.
        • Smit J.H.
        • Hooijer C.
        • van Tilburg W.
        Major and minor depression in later life.
        J Affect Disord. 1995; 36: 65-75
        • Berkman L.F.
        • Berkman C.S.
        • Kasl S.
        Depressive symptoms in relation to physical health and functioning in the elderly.
        Am J Epidemiol. 1986; 124: 372-388
        • Black S.
        • Goodwin J.
        • Markides K.
        The association between chronic diseases and depressive symptomology in older Mexican Americans.
        J Gerontol Med Sci. 1998; 53: M118-M194
        • Blazer D.
        Depression in late life.
        Med Sci. 2003; 58A: 249-265
        • Blazer D.
        • Bachar J.
        • Hughes D.
        Major depression with melancholia.
        J Am Geriatr Soc. 1987; 35: 927-932
        • Blazer D.
        • George L.K.
        • Hughes D.
        The epidemiology of anxiety disorders.
        in: Salzman C. Lebowitz B.D. Anxiety in the Elderly Treatment and Research. Springer, . New York1991: 17-30
        • Blazer D.
        • Landerman L.
        • Hays J.
        • Simonsick E.
        • Saunders W.
        Symptoms of depression among community-dwelling elderly African-American and White older adults.
        Psychol Med. 1998; 28: 1311-1320
        • Blazer D.
        • Moody-Ayers S.
        • Craft-Morgan J.
        • Burchett B.
        Depression in diabetes and obesity.
        J Psychosom Res. 2002; 52: 1-4
        • Blazer D.
        • Swartz M.
        • Woodbury M.
        • Manton K.G.
        • Hughes D.
        • George L.K.
        Depressive symptoms and depressive diagnoses in a community population.
        Arch Gen Psychiatry. 1988; 45: 1078-1084
        • Blazer D.G.
        Dysthymia in community and clinical samples of older adults.
        Am J Psychiatry. 1994; 151: 1567-1569
        • Blazer D.G.
        Is depression more frequent in late life? An honest look at the evidence.
        Am J Geriatr Psychiatry. 1994; 2: 193-199
        • Blazer D.G.
        Psychiatry and the oldest old.
        Am J Psychiatry. 2000; 157: 1915-1924
        • Broadhead W.E.
        • Blazer D.G.
        • George L.K.
        • Tse C.K.
        Depression, disability days, and days lost from work.
        JAMA. 1990; 264: 2524-2528
        • Brodarty H.
        • Luscombe G.
        • Parker G.
        • Wilhelm K.
        • Hickie I.
        • Austin M.
        • et al.
        Early and late onset depression in old age.
        J Affect Disord. 2001; 66: 225-236
        • Charles S.
        • Reynolds C.
        • Gatz M.
        Age-related differences and changes in positive and negative affect over 23 years.
        J Pers Soc Psychol. 2001; 80: 136-151
        • Devenand D.
        • Noble M.
        • Singer T.
        • Kiersky J.
        • Turret N.
        • Roose S.
        • et al.
        Is dysthymia a different disorder in the elderly?.
        Am J Psychiatry. 1994; 151: 1592-1599
        • Diefenbach G.
        • Hopko D.
        • Feigon S.
        • Stanley M.
        • Novy D.
        • Beck J.
        • et al.
        “Minor GAD:” Characteristics of subsyndromal GAD in older adults.
        Behav Res Ther. 2002; 41: 481-487
        • Ellor J.R.
        • Kurz D.J.
        Misuse and abuse of prescription and nonprescription drugs by the elderly.
        Nurs Clin North Am. 1982; 17: 319-330
        • Evans J.D.
        • Heaton R.K.
        • Paulsen J.S.
        • McAdams L.A.
        • Heaton S.C.
        • Jeste D.V.
        Schizoaffective disorder.
        J Clin Psychiatry. 1999; 60: 874-882
        • Evans J.D.
        • Paulsen J.S.
        • Harris M.J.
        • Heaton R.K.
        • Jeste D.V.
        A clinical and neuropsychological comparison of delusional disorder and schizophrenia.
        J Neuropsychiatr Clin Neurosci. 1996; 8: 281-286
        • Flint A.J.
        Epidemiology and comorbidity of anxiety disorders in the elderly.
        Am J Psychiatry. 1994; 151: 640-649
        • Gallo J.
        • Rabins P.
        • Anthony J.
        Sadness in older persons.
        Psychol Med. 1999; 29: 341-350
        • Gallo J.J.
        • Rabins P.V.
        • Lyketsos C.G.
        • Tien A.Y.
        • Anthony J.C.
        Depression without sadness.
        J Am Geriatr Soc. 1997; 45: 570-578
        • Harris M.J.
        • Jeste D.V.
        Late-onset schizophrenia.
        Schizophr Bull. 1988; 14: 39-55
        • Hickie I.
        • Scott E.
        • Naismith S.
        • Ward P.
        • Turner K.
        • Parker G.
        • et al.
        Late-onset depression.
        Psychol Med. 2001; 31: 1403-1412
        • Horowitz A.
        Creating Mental Illness. University of Chicago Press, Chicago2002
        • Howard R.
        • Almeida O.
        • Levy R.
        Phenomenology, demography and diagnosis in late paraphrenia.
        Psychol Med. 1994; 24: 397-410
        • Howard R.
        • Castle D.
        • Wessely S.
        • Murray R.M.
        A comparative study of 470 cases of early and late-onset schizophrenia.
        Br J Psychiatry. 1993; 163: 352-357
        • Howard R.
        • Rabins P.V.
        • Seeman M.V.
        • Jeste D.V.
        • International Late-Onset Schizophrenia Group
        Late-onset schizophrenia and very-late-onset schizophrenia-like psychosis.
        Am J Psychiatry. 2000; 157: 172-178
        • Hybels C.
        • Blazer D.
        Epidemiology and geriatric psychiatry.
        in: Tsuang M. Tohen M. Psychiatric Epidemiology. John Wiley & Sons, . New York2003: 603-628
        • Hybels C.
        • Blazer D.
        • Pieper C.
        Toward a threshold for subthreshold depression.
        Gerontologist. 2001; 41: 357-365
        • Jeste D.V.
        • Alexopoulos G.S.
        • Bartels S.J.
        • Cummings J.
        • Gallo J.J.
        • Gottlieb G.L.
        • et al.
        Consensus statement on the upcoming crisis in geriatric mental health.
        Arch Gen Psychiatry. 1999; 56: 848-853
        • Jeste D.V.
        • Finkel S.I.
        Psychosis of Alzheimer’s disease and related dementias.
        Am J Geriatr Psychiatry. 2000; 8: 29-34
        • Jeste D.V.
        • Harris M.J.
        • Krull A.
        • Kuck J.
        • McAdams L.A.
        • Heaton R.
        Clinical and neuropsychological characteristics of patients with late-onset schizophrenia.
        Am J Psychiatry. 1995; 152: 722-730
        • Jeste D.V.
        • Heaton S.C.
        • Paulsen J.S.
        • Ercoli L.
        • Harris M.J.
        • Heaton R.K.
        Clinical and neuropsychological comparison of psychotic depression with nonpsychotic depression and schizophrenia.
        Am J Psychiatry. 1996; 153: 490-496
        • Jeste D.V.
        • McAdams L.A.
        • Palmer B.W.
        • Braff D.
        • Jernigan T.L.
        • Stout J.
        • et al.
        Relationship of neuropsychological and MRI measures with age of onset of schizophrenia.
        Acta Psychiatr Scand. 1998; 98: 156-164
        • Jeste D.V.
        • Symonds L.L.
        • Harris M.J.
        • Paulsen J.S.
        • Palmer B.W.
        • Heaton R.K.
        Non-dementia non-praecox dementia praecox? Late-onset schizophrenia.
        Am J Geriatr Psychiatry. 1997; 5: 302-317
        • Judd L.L.
        • Akiskal H.S.
        The clinical and public health relevance of current research on subthreshold depressive symptoms to elderly patients.
        Am J Geriatr Psychiatry. 2002; 10: 233-238
        • Kessler R.
        • Merikangas K.
        • Berglund P.
        • Eaton W.
        • Koretz D.
        • Walters E.
        Mild disorders should not be eliminated from DSM-V.
        Arch Gen Psychiatry. 2003; 60: 1117-1122
        • King C.J.
        • VanHasselt V.B.
        • Segal D.L.
        • Hersen M.
        Diagnosis and assessment of substance abuse in older adults.
        Addict Behav. 1994; 19: 41-55
        • Kivela S.
        • Pahkala K.
        • Laippala P.
        Prevalence of depression in an elderly Finnish population.
        Acta Psychiatr Scand. 1988; 78: 401-413
        • Kraemer H.
        • Stice E.
        • Kazdin A.
        • Offord D.R.
        • Kupfer D.
        How do risk factors work together? Mediators, moderators, and independent, overlapping, and proxy risk factors.
        Am J Psychiatry. 2001; 158: 848-856
        • Kraemer H.C.
        • Wilson T.
        • Fairburn C.G.
        • Agras W.S.
        Mediators and moderators of treatment effects in randomized clinical trials.
        Arch Gen Psychiatry. 2002; 59: 877-883
        • Krishnan K.
        • Hays J.
        • Blazer D.
        MRI-defined vascular depression.
        Am J Psychiatry. 1997; 154: 497-501
        • Lindesay J.
        Phobic disorders in the elderly.
        Br J Psychiatry. 1991; 159: 531-541
        • Lockwood K.A.
        • Alexopoulos G.S.
        • Van Gorp W.G.
        Executive dysfunction in geriatric depression.
        Am J Psychiatry. 2002; 159: 1119-1126
        • Lyketsos C.
        • Baker L.
        • Warren A.
        • Steele C.
        • Brandt J.
        • Steinberg M.
        Major and minor depression in Alzheimer’s disease.
        J Neuropsychiatr Clin Neurosci. 1997; 9: 556-561
        • Magaziner J.
        • Simonsick E.
        • Kashner M.
        Predictors of functional recovery in the year following hospital discharge for hip fracture.
        J Gerontol Med Sci. 1990; 45 (M1-10–M107)
        • Meyers B.S.
        Geriatric delusional depression.
        Clin Geriatr Med. 1992; 8: 299-308
        • Miller N.
        • Belkin B.
        • Gold M.
        Alcohol and drug dependence among the elderly.
        Compr Psychiatry. 1991; 32: 153-165
        • Newman J.
        Aging and depression.
        Psychol Aging. 1989; 4: 150-165
        • Newman J.
        • Engel R.
        • Jensen J.
        Age differences in depressive symptom experiences.
        J Gerontol. 1991; 46: 224-235
        • Olin J.T.
        • Katz I.R.
        • Meyers B.S.
        • Schneider L.S.
        • Lebowitz B.D.
        Provisional diagnostic criteria for depression of Alzheimer disease.
        Am J Geriatr Psychiatry. 2002; 10: 129-141
        • Palmer B.W.
        • Jeste D.V.
        • Sheikh J.I.
        Anxiety disorders in the elderly.
        J Affect Disord. 1997; 46: 183-190
        • Palmer B.W.
        • McClure F.
        • Jeste D.V.
        Schizophrenia in late-life.
        Harv Rev Psychiatry. 2001; 9: 51-58
        • Parker G.
        Classifying depression.
        Am J Psychiatry. 2000; 157: 1195-1203
        • Parker G.
        • Hadzi-Pavlovic D.
        Melancholia. Cambridge University Press, New York1996
        • Parker G.
        • Roy K.
        • Hadzi-Pavlovic D.
        • Wilhelm K.
        • Mitchell P.
        The differential impact of age on the phenomenology of melancholia.
        Psychol Med. 2001; 31: 1231-1236
        • Parmlee P.
        • Katz I.
        • Lawton M.P.
        Anxiety and its association with depression among institutionalized elderly.
        J Geriatr Psychiatry. 1993; 1: 46-58
        • Patterson M.
        • Schnell A.
        • Martin R.
        • Mendez M.
        • Smyth K.
        Assessment of behavioral and affective symptoms in Alzheimer’s disease.
        J Geriatr Psychiatry Neurol. 1990; 3: 21-30
        • Patterson T.L.
        • Jeste D.V.
        The potential impact of the baby-boom generation on substance abuse among elderly persons.
        Psychiatr Serv. 1999; 50: 1184-1188
        • Pearlson G.D.
        • Kreger L.
        • Rabins R.V.
        • Chase G.A.
        • Cohen B.
        • Wirth J.B.
        • et al.
        A chart review study of late-onset and early-onset schizophrenia.
        Am J Psychiatry. 1989; 146: 1568-1574
        • Pearlson G.D.
        • Tune L.E.
        • Wong D.F.
        • Aylward E.H.
        • Barta P.E.
        • Powers R.E.
        • et al.
        Quantitative D2 dopamine receptor PET and structural MRI changes in late onset schizophrenia.
        Schizophr Bull. 1993; 19: 783-795
        • Rabins P.V.
        • Pauker S.
        • Thomas J.
        Can schizophrenia begin after age 44?.
        Compr Psychiatry. 1984; 25: 290-293
        • Radloff L.S.
        The CES-D Scale.
        Appl Psychol Measurement. 1977; 1: 385-401
        • Regier D.A.
        • Boyd J.H.
        • Burke J.D.J.
        • Rae D.S.
        • Myers J.K.
        • Kramer M.
        • et al.
        One-month prevalence of mental disorders in the United States.
        Arch Gen Psychiatry. 1988; 45: 977-986
        • Reifler B.
        • Larson E.
        • Hanley R.
        Coexistence of cognitive impairment and depression in geriatric outpatients.
        Am J Psychiatry. 1982; 139: 623-626
        • Robinson R.
        • Price T.
        Post-stroke depressive disorders.
        Stroke. 1982; 13: 635-641
        • Rogers MP
        • White K
        • Warshaw MG
        • Yonkers KA
        • Rodriguez-Villa F
        • Chang G
        • et al.
        Prevalence of medical illness in patients with anxiety disorders.
        Int J Psychiatry Med. 1994; 24: 83-96
        • Ross C.
        • Mirowsky J.
        Components of depressed mood in married men and women.
        Am J Epidemiol. 1984; 122: 997-1004
        • Rubin E.
        • Veiel L.
        • Kinscherf D.
        • Morris J.
        • Storandt M.
        Clinically significant depressive symptoms and very mild to mild dementia of the Alzheimer type.
        J Geriatr Psychiatry. 2001; 16: 694-701
        • Sachdev P.
        • Brodaty H.
        • Rose N.
        • Haindl W.
        Regional cerebral blood flow in late-onset schizophrenia.
        Schizophr Res. 1997; 27: 105-117
        • Salloway S.
        • Malloy P.
        • Kohn R.
        • Gillard E.
        • Duffy J.
        • Rogg J.
        • et al.
        MRI and neuropsychological differences in early- and late-life-onset geriatric depression.
        Neurology. 1996; 46: 1567-1574
        • Sheikh J.I.
        Anxiety disorders and their treatment.
        Clin Geriatr Med. 1992; 8: 411-426
        • Snaith R.
        The concepts of mild depression.
        Br J Psychiatry. 1987; 150: 387-393
        • Sullivan M.
        • LaCroix A.
        • Baum C.
        Functional status in coronary artery disease.
        Am J Med. 1997; 103: 348-356
        • Tweed D.
        • Blazer D.
        • Ciarlo J.
        Psychiatric epidemiology in elderly populations.
        in: Wallace R.B. Woolson R.F. The Epidemiologic Study of the Elderly. Oxford University Press, New York1992: 213-233
        • Weiner M.F.
        • Edland S.D.
        • Luszczynska H.
        Prevalence and incidence of major depression in Alzheimer’s Disease.
        Am J Psychiatry. 1994; 151: 1006-1009
        • Williams J.W.
        • Barrett J.
        • Oxman T.
        • Frank E.
        • Katon W.
        • Sullivan M.
        • et al.
        Treatment of dysthymia and minor depression in primary care.
        JAMA. 2000; 284: 1519-1526