Background
Smooth pursuit and antisaccade abnormalities are well documented in schizophrenia,
but their neuropathological correlates remain unclear.
Methods
In this study, we used statistical parametric mapping to investigate the relationship
between oculomotor abnormalities and brain structure in a sample of first-episode
schizophrenia patients (n = 27). In addition to conventional volumetric magnetic resonance
imaging, we also used magnetization transfer ratio, a technique that allows more precise
tissue characterization.
Results
We found that smooth pursuit abnormalities were associated with reduced magnetization
transfer ratio in several regions, predominantly in the right prefrontal cortex. Antisaccade
errors correlated with gray matter volume in the right medial superior frontal cortex
as measured by conventional magnetic resonance imaging but not with magnetization
transfer ratio.
Conclusions
These preliminary results demonstrate that specific structural abnormalities are associated
with abnormal eye movements in schizophrenia.
Key words
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Article info
Publication history
Accepted:
August 2,
2004
Received in revised form:
July 29,
2004
Received:
February 1,
2004
Identification
Copyright
© 2004 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
