Background
DISC1 has been suggested as a causative gene for psychoses in a large Scottish family.
We recently identified FEZ1 as an interacting partner for DISC1. To investigate the
role of FEZ1 in schizophrenia and bipolar disorder, case–control association analyses
were conducted in Japanese cohorts.
Methods
We performed a mutation screen of the FEZ1 gene and detected 15 polymorphisms. Additional
data on informative polymorphisms were obtained from public databases. Eight single
nucleotide polymorphisms (SNPs) were analyzed in 119 bipolar disorder and 360 schizophrenic
patients and age- and gender-matched control subjects. All genotypes were determined
with the TaqMan assay, and selected samples were confirmed by sequencing.
Results
The two adjacent polymorphisms displayed a nominally significant association with
schizophrenia (IVS2+1587G>A, p = .014; 396T<A or Asp123Glu, p = .024). Homozygotes with the Glu123 allele were observed in only a small portion
(2%) of schizophrenia patients but not in control subjects or bipolar patients. Conversely,
no SNPs displayed allelic, genotypic, or haplotypic associations with bipolar disorder.
Conclusions
A modest association between FEZ1 and schizophrenia suggests that this gene and the
DISC1-mediated molecular pathway might play roles in the development of schizophrenia,
with FEZ1 affecting only a small subset of Japanese schizophrenia patients.
Key words
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Article info
Publication history
Accepted:
August 26,
2004
Received in revised form:
August 9,
2004
Received:
February 19,
2004
Identification
Copyright
© 2004 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
