Brief report| Volume 56, ISSUE 9, P698-700, November 01, 2004

Association of AKT1 with schizophrenia confirmed in a Japanese population


      Abnormality of the V-akt murine thymoma viral oncogene homologue 1 (AKT1) may be a predisposing factor in schizophrenia. Recent evidence supporting this hypothesis showed decreased AKT1 protein levels in patients with schizophrenia and significant association of AKT1 haplotypes according to the transmission disequilibrium test.


      We provide the first replication of this evidence using a relatively large case–control sample (507 Japanese schizophrenia and 437 control subjects). We genotyped five single nucleotide polymorphisms (SNPs) from the original study and one additional SNP.


      We found a positive association with an SNP (SNP5) different from the original study’s findings (SNP3) and also significance in the haplotypes constructed from the combination of SNP5. Linkage disequilibrium around SNP5 was complex and may produce this positive association.


      Our study provides support for the theory that AKT1 is a susceptibility gene for Japanese schizophrenia. Fine linkage disequilibrium mapping is required for a conclusive result.

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      • Erratum
        Biological PsychiatryVol. 66Issue 5
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          A labeling error has been discovered in “Association of AKT1 with schizophrenia confirmed in a Japanese population” by Ikeda et al., which appeared in Biological Psychiatry, Volume 56, Number 9 (2004; 56:698–700). Specifically, for rs2494732 (SNP5), the identities of the common and rare frequency nucleotides were inadvertently reversed by the authors, so that G is replaced by A and vice versa.
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