Advertisement
Editorial| Volume 54, ISSUE 12, P1310-1311, December 15, 2003

Methylphenidate-induced plasticity: what should we be looking for?

      Attention deficit hyperactivity disorder (ADHD) is a serious condition that results in diverse negative outcomes, including poor school performance, difficulties with peers and family, increased rates of substance use, and elevated risk of other psychiatric disorders. Fortunately, or so it would seem, the stimulant drugs have been found to be safe and effective for the treatment of ADHD. Indeed, methylphenidate is the best-studied drug in pediatric psychopharmacology (
      MTA Cooperative Group
      A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD.
      ), and decades of experience bolster reassuring evidence from clinical trials. Despite these positive findings, stimulant drugs have long been administered under a cloud of suspicion.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Andersen S.L.
        • Arvanitogiannis A.
        • Pliakas A.M.
        • LeBlanc C.
        • Carlezon Jr, W.A.
        Altered responsiveness to cocaine in rats exposed to methylphenidate during development.
        Nat Neurosci. 2002; 5: 13-14
        • Angold A.
        • Erkanli A.
        • Egger H.L.
        • Costello E.J.
        Stimulant treatment for children.
        J Am Acad Child Adolesc Psychiatry. 2000; 8: 975-984
        • Biederman J.
        • Wilens T.
        • Mick E.
        • Spencer T.
        • Faraone S.V.
        Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder.
        Pediatrics. 1999; 104: e20
      1. Bolaños CA, Barrot M, Berton O, Wallace-Black D, Nestler EJ (2003): Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood. Biol Psychiatry 54:1317–1329

        • Brandon C.L.
        • Marinelli M.
        • Baker L.K.
        • White F.J.
        Enhanced reactivity and vulnerability to cocaine following methylphenidate treatment in adolescent rats.
        Neuropsychopharmacol. 2001; 25: 651-661
      2. Brandon CL, Marinelli M, White FJ (2003): Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons. Biol Psychiatry 54:1338–1344

      3. Carlezon WA Jr, Mague SD, Andersen SL (2003): Enduring behavioral effects of early exposure to methylphenidate in rats. Biol Psychiatry 54:1330–1337

        • MTA Cooperative Group
        A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD.
        Arch Gen Psychiatry. 1999; 56: 1073-1086
        • Wilens T.E.
        • Faraone S.V.
        • Biederman J.
        • Gunwardene S.
        Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature.
        Pediatrics. 2003; 111: 179-186
        • Zito J.M.
        • Safer D.J.
        • dosReis S.
        • Gardner J.F.
        • Boles M.
        • Lynch F.
        Trends in the prescribing of psychotropic medications to preschoolers.
        JAMA. 2000; 283: 1025-1030