Abstract
Background
A neonatal hippocampal lesion induces postpubertal behavioral alterations resembling
phenomena observed in schizophrenia. We have recently reported that nucleus accumbens
neurons exhibit altered response to ventral tegmental area activation, but only when
animals with this lesion reach adulthood. Because a prefrontal cortical lesion eliminates
postpubertal abnormal behaviors in these animals, we investigated whether altered
accumbens responses were reversed with this manipulation.
Methods
In vivo intracellular recordings were conducted in accumbens neurons in rats that
had received neonatal hippocampal lesions combined with either adult prefrontal cortical
lesion or sham treatment. Accumbens response to mesolimbic pathway activation was
recorded in these animals.
Results
Accumbens neurons from animals with a neonatal hippocampal lesion and an adult prefrontal
sham operation still showed altered accumbens response to mesolimbic stimulation.
On the other hand, most animals with combined neonatal hippocampal and adult prefrontal
lesions exhibited responses similar to those of naïve animals.
Conclusions
This result suggests that abnormal behaviors in these animals might be related to
excessive prefrontal drive of accumbens neurons upon dopamine activation.
Keywords
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Article info
Publication history
Accepted:
July 14,
2003
Received in revised form:
June 19,
2003
Received:
April 11,
2003
Identification
Copyright
© 2004 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
