Abstract
Gene expression arrays and proteomics together provide a great opportunity to reveal
the molecular pathophysiology of psychiatric disorders; however, their potential will
not be realized unless due attention is paid to the cellular heterogeneity of the
brain and the likely differential neuropathological involvement of specific neuronal
and glial cell types. Hence, methods are needed which can procure homogeneous populations
of cells as a source of messenger RNA, protein, or DNA. Laser-assisted microdissection
techniques provide such a tool. Here we briefly discuss the principles, applications,
and limitations of laser-assisted microdissection in psychiatric research.
Keywords
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Article info
Publication history
Accepted:
June 16,
2003
Received in revised form:
May 30,
2003
Received:
March 28,
2003
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
