Abstract
Background
Decreased sensitivity to and increased tolerance for the effects of alcohol is a phenotype,
which was shown to be associated with an increased risk for alcoholism in humans and
was observed in protein tyrosine kinase (PTK) fyn knockout mice.
Methods
We performed an association study of genetic variations of PTK fyn in 430 alcohol-dependent
patients and 365 unrelated control subjects from two independent samples.
Results
In a combined analysis, we found an association of alcohol dependence with the single
nucleotide polymorphism (SNP) T137346C in the 5′ untranslated region (UTR) of the
gene. A relevant association could be excluded for the remaining two informative SNPs.
Selection by phenotype showed that a high number of withdrawal symptoms, high amount
of alcohol intake, and high maximum number of drinks compared with unrelated control
subjects was associated with the SNP in the 5′-UTR region but not with the remaining
SNPs.
Conclusions
Our results indicate a possible association of alcohol dependence with a genotype
of the SNP T137346C of the PTK fyn, with C being the risk allele.
Keywords
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Article info
Publication history
Accepted:
June 6,
2003
Received in revised form:
May 12,
2003
Received:
December 2,
2002
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
