Abstract
Background
Response inhibition is an executive function that requires voluntary control over
responses when there is a change of context. The right inferior frontal cortex is
necessary for response inhibition, and a deficit in right frontostriatal circuitry
might underlie attention-deficit/hyperactivity disorder (ADHD). Many studies of childhood
ADHD have demonstrated impaired response inhibition and its amelioration by methylphenidate
(MPH). The current study tested response inhibition and the effect of MPH in adult
ADHD.
Methods
Response inhibition was assessed with the “tracking” stop-signal test in 13 adults
with a diagnosis of ADHD, both while taking and while not taking medication, and 13
healthy, unmedicated, age- and intelligence quotient–matched control subjects.
Results
Stop-signal reaction time was significantly slower in unmedicated adults with ADHD
relative to healthy control subjects, and this deficit was significantly ameliorated
by medication.
Conclusions
Adult ADHD patients had a response inhibition profile similar to that produced by
lesions to the right inferior frontal cortex, which was remedied by stimulant medication.
Keywords
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Article info
Publication history
Accepted:
June 3,
2003
Received in revised form:
June 2,
2003
Received:
February 23,
2003
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
