Abstract
Background
The attempts to evaluate amygdaloid volumes using magnetic resonance imaging (MRI)
in patients with schizophrenia have yielded highly divergent results.
Methods
Volumes of the amygdala were measured in 22 healthy participants and 18 neuroleptic-naive
patients with first-episode schizophrenia, while controlling for intracranial area,
gender, age, and handedness.
Results
Persons with schizophrenia presented significantly lower amygdaloid volumes bilaterally.
No significant correlations were found between the amygdaloid volumes and either the
duration of the disease or the symptom severity.
Conclusions
Amygdaloid volume anomalies are already present in the early phases of schizophrenia.
Keywords
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Article info
Publication history
Accepted:
May 30,
2003
Received in revised form:
May 27,
2003
Received:
February 3,
2003
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
