Abstract
Conditional genetic modifications are used to determine how individual molecules contribute
to the function of defined neuronal circuits in the mouse brain. Among various techniques
for these genetic modifications, the tetracycline transactivator and the Cre-loxP
systems have proved to be most successful in recent years. Here we describe the basic
principles, recent developments, and potential applications of these methodologies.
We discuss their impact on the study of general brain function and their use for modeling
different brain disorders.
Keywords
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Article info
Publication history
Accepted:
April 21,
2003
Received in revised form:
April 16,
2003
Received:
January 30,
2003
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
