Abstract
Background
Evidence suggests that a disruption in limbic system network integrity and, in particular,
the cingulate gyrus (CG), may play a role in the pathophysiology of schizophrenia;
however, the cingulum bundle (CB), the white matter tract furnishing both input and
output to CG, and the most prominent white matter fiber tract in the limbic system,
has not been evaluated in schizophrenia using the new technology of diffusion tensor
imaging (DTI).
Methods
We used line scan DTI to evaluate diffusion in the CB in 16 male schizophrenia patients
and 18 male control subjects, group-matched for age, parental socioeconomic status,
and handedness. We acquired 4-mm-thick coronal slices through the entire brain. Maps
of fractional anisotropy (FA) were generated to quantify diffusion within the left
and right CB on eight slices that included the central portion of the CB.
Results
Results showed group differences, bilaterally, in area and mean FA for CB, where patients
showed smaller area and less anisotropy than controls. For patients, decreased left
CB correlated significantly with attention and working memory measures as assessed
by the Wisconsin Card Sorting Test.
Conclusions
These data provide strong evidence for CB disruptions in schizophrenia, which may
be related to disease-related attention and working memory abnormalities.
Keywords
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Article info
Publication history
Accepted:
April 2,
2003
Received in revised form:
April 1,
2003
Received:
December 23,
2002
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
