Brief report| Volume 54, ISSUE 9, P947-949, November 01, 2003

Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma



      This study investigated the efficacy of propranolol prescribed shortly after trauma exposure in the prevention of posttraumatic stress disorder (PTSD) symptoms and diagnosis.


      Eleven patients received 40 mg of propranolol 3 times daily for 7 days, followed by a taper period of 8–12 days. They were compared with eight patients who refused propranolol but agreed to participate in the study. Though nonrandomized, the two groups did not differ on demographics, exposure characteristics, physical injury severity, or peritraumatic emotional responses.


      Posttraumatic stress disorder rates were higher in the group who refused propranolol (3/8) compared with those who received the medication (1/11), as were the levels of PTSD symptoms (U = 85, p = .037).


      Our results are consistent with earlier findings and suggest that propranolol may be useful for mitigating PTSD symptoms or perhaps even preventing the development of PTSD.


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        • Blanchard E.B.
        • Hickling E.J.
        • Galovski T.
        • Veasey C.
        Emergency room vital signs and PTSD in a treatment seeking sample of motor vehicle accident survivors.
        J Trauma Stress. 2002; 15/3: 199-204
        • Brunet A.
        • Weiss D.S.
        • Metzler T.J.
        • Best S.R.
        • Neylan T.C.
        • Rogers C.
        • et al.
        The Peritraumatic Distress Inventory.
        Am J Psychiatry. 2001; 158: 1480-1485
        • Bryant R.A.
        • Harvey A.G.
        • Guthrie R.M.
        • Moulds M.L.
        A prospective study of psychophysiological arousal, acute stress disorder and post-traumatic stress disorder.
        J Abnorm Psychol. 2000; 109: 341-344
        • Cahill L.
        • Prins B.
        • Weber M.
        • McGaugh J.L.
        Beta-adrenergic activation and memory for emotional events.
        Nature. 1994; 371: 702-704
        • Davidson J.R.
        • Colket J.T.
        The eight-item treatment-outcome post-traumatic stress disorder scale.
        Int Clin Psychopharmacol. 1997; 12: 41-45
        • Goddard A.W.
        • Charney D.S.
        Toward an integrated neurobiology of panic disorder.
        J Clin Psychiatry. 1997; 58: 4-11
        • Laverdure B.
        • Boulenger J.P.
        Beta-blocking drugs and anxiety. A proven therapeutic value.
        Encephale. 1991; 17: 481-492
        • Lecrubier Y.
        • Sheehan D.
        • Weiller E.
        • Amorin P.
        • Bonora I.
        • Sheehan K.
        • et al.
        The Mini International Neuropsychiatric Interview (M.I.N.I.), a short diagnostic interview.
        Eur Psychiatry. 1997; 12: 232-241
        • Orr S.P.
        • Metzger L.J.
        • Lasko N.B.
        • Macklin M.L.
        • Peri T.
        • Pitman R.K.
        De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder.
        J Abnorm Psychol. 2000; 109: 290-298
        • Pitman R.K.
        • Sanders K.M.
        • Zusman R.M.
        • Healy A.R.
        • Cheema F.
        • Lasko N.B.
        • et al.
        Pilot study of secondary prevention of posttraumatic stress disorder with propranolol.
        Biol Psychiatry. 2002; 51: 189-192
        • Shalev A.Y.
        Biological responses to disasters.
        Psychiatry Q. 2000; 71: 277-288
        • Shalev A.Y.
        • Sahar T.
        • Freedman S.
        • Peri T.
        • Glick N.
        • Brandes D.
        • et al.
        A prospective study of heart rate response following trauma and the subsequent development of posttraumatic stress disorder.
        Arch Gen Psychiatry. 1998; 55: 553-559
        • Smith T.
        Trauma index revisited.
        Crit Care Med. 1990; 18: 174-180
        • Southwick S.M.
        • Bremner J.D.
        • Rasmusson A.
        • Morgan C.A.
        • Arnsten A.
        • Charney D.S.
        Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder.
        Biol Psychiatry. 1999; 46: 1192-1204

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