Abstract
Background
Alterations in cytokine levels in patients with schizophrenia have been documented.
Polymorphisms in these cytokine genes are thus potential genetic markers for schizophrenia.
The aim of this study was to investigate four biallelic polymorphisms in the tumor
necrosis factor-α (TNFα) gene promoter in relation to susceptibility to schizophrenia.
Methods
Three hundred two patients and 152 control subjects were genotyped and frequencies
of genotypes and alleles were compared for the −1031T/C, −863C/A, −857C/T, and −308G/A
polymorphisms. Genotype and allele frequencies were compared between controls and
patients.
Results
There were statistically significant differences in genotype distribution and allele
frequencies for the −308 polymorphism (p < .001). Genotype distribution and allele frequencies of the other three polymorphisms
were not different between patients and reference controls.
Conclusions
The −308 polymorphism or another genetic variant in linkage disequilibrium with it
could be a susceptibility factor for chronic schizophrenia.
Keywords
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Article info
Publication history
Accepted:
March 21,
2003
Received in revised form:
March 4,
2003
Received:
October 8,
2002
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
