Advertisement
Original article| Volume 54, ISSUE 11, P1154-1161, December 01, 2003

Levels-of-processing effect on word recognition in schizophrenia

      Abstract

      Background

      Individuals with schizophrenia have difficulty organizing words semantically to facilitate encoding. This is commonly attributed to organizational rather than semantic processing limitations. By requiring participants to classify and encode words on either a shallow (e.g., uppercase/lowercase) or deep level (e.g., concrete/abstract), the levels-of-processing paradigm eliminates the need to generate organizational strategies.

      Methods

      This paradigm was administered to 30 patients with schizophrenia and 30 healthy comparison subjects to test whether providing a strategy would improve patient performance.

      Results

      Word classification during shallow and deep encoding was slower and less accurate in patients. Patients also responded slowly during recognition testing and maintained a more conservative response bias following deep encoding; however, both groups showed a robust levels-of-processing effect on recognition accuracy, with unimpaired patient performance following both shallow and deep encoding.

      Conclusions

      This normal levels-of-processing effect in the patient sample suggests that semantic processing is sufficiently intact for patients to benefit from organizational cues. Memory remediation efforts may therefore be most successful if they focus on teaching patients to form organizational strategies during initial encoding.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Aleman A.
        • Hijman R.
        • de Haan E.H.F.
        • Kahn R.S.
        Memory impairment in schizophrenia.
        Am J Psychiatry. 1999; 156: 1358-1366
        • Allen H.A.
        • Frith C.D.
        Selective retrieval and free emission of category exemplars in schizophrenia.
        Br J Psychology. 1983; 74: 481-490
        • American Psychiatric Association
        Diagnostic and Statistical Manual of Mental Disorders. 4th ed. American Psychiatric Press, Washington, DC1994
        • Andreasen N.C.
        The Scale for the Assessment of Negative Symptoms (SANS). The University of Iowa, Iowa City, Iowa1984
        • Andreasen N.C.
        The Scale for the Assessment of Positive Symptoms (SAPS). The University of Iowa, Iowa City, Iowa1984
        • Arango C.
        • Bartko J.J.
        • Gold J.M.
        • Buchanan R.
        Prediction of neuropsychological performance by neurological signs in schizophrenia.
        Am J Psychiatry. 1999; 156: 1349-1357
        • Blanchard J.J.
        • Neale J.M.
        The neuropsychological signature of schizophrenia.
        Am J Psychiatry. 1994; 151: 40-48
        • Brébion G.
        • Amador X.
        • David A.
        • Malaspina D.
        • Sharif Z.
        • Gorman J.M.
        Positive symptomatology and source-monitoring failure in schizophrenia—an analysis of symptom-specific effects.
        Psychiatry Res. 2000; 95: 119-131
        • Brébion G.
        • Amador X.
        • Smith M.J.
        • Gorman J.M.
        Mechanisms underlying memory impairment in schizophrenia.
        Psychol Med. 1997; 27: 383-393
        • Brébion G.
        • Amador X.
        • Smith M.J.
        • Malaspina D.
        • Sharif Z.
        • Gorman J.M.
        Opposite links of positive and negative symptomatology with memory errors in schizophrenia.
        Psychiatry Res. 1999; 88: 15-24
        • Buckner R.L.
        • Koutstaal W.
        • Schacter D.L.
        • Dale A.M.
        • Rotte M.
        • Rosen B.R.
        Functional-anatomic study of episodic retrieval using fMRI II. Selective averaging of event-related fMRI trials to test the retrieval success hypothesis.
        Neuroimage. 1998; 7: 163-175
        • Buckner R.L.
        • Koutstaal W.
        • Schacter D.L.
        • Wagner A.D.
        • Rosen B.F.
        Functional-anatomic study of episodic retrieval using fMRI I. Retrieval effort versus retrieval success.
        Neuroimage. 1998; 7: 151-162
        • Calev A.
        Recall and recognition in chronic non-demented schizophrenics.
        J Abnorm Psychol. 1984; 93: 172-177
        • Chan A.S.
        • Kwok I.C.
        • Chiu H.
        • Lam L.
        • Pang A.
        • Chow L.
        Memory and organizational strategies in chronic and acute schizophrenic patients.
        Schizophr Res. 2000; 41: 431-445
        • Chute D.L.
        • Westall R.F.
        PowerLaboratory for MacOS. BrooksCole Publishing/MacLaboratory, Inc, Devon, PA1996
        • Cohen J.
        Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Erlbaum, Hillsdale, NJ1988
        • Corwin J.
        • Peselow E.
        • Feenan K.
        • Rotrosen J.
        • Fieve R.
        Disorders of decision in affective disease.
        Biol Psychiatry. 1990; 27: 813-833
        • Craik F.
        • Lockhart R.
        Levels of processing.
        J Verbal Learn Verbal Behav. 1972; 11: 671-684
        • Danion J.-M.
        • Rizzo L.
        • Bruant A.
        Functional mechanisms underlying impaired recognition memory and conscious awareness in patients with schizophrenia.
        Arch Gen Psychiatry. 1999; 56: 639-644
        • Demb J.B.
        • Desmond J.E.
        • Wagner A.D.
        • Vaidya C.J.
        • Glover G.H.
        • Gabrieli J.D.E.
        Semantic encoding and retrieval in the left inferior prefrontal cortex.
        J Neurosci. 1995; 15: 5870-5878
        • Frith C.D.
        The Cognitive Neuropsychology of Schizophrenia. Lawrence Erlbaum, Hove, UK1992
        • Gold J.M.
        • Randolf C.
        • Carpenter C.J.
        • Goldberg T.E.
        • Weinberger D.R.
        Forms of memory failure in schizophrenia.
        J Abnorm Psychol. 1992; 101: 487-494
        • Goldberg T.E.
        • Aloia M.S.
        • Gourovitch M.L.
        • Missar D.
        • Pickar D.
        • Weinberger D.R.
        Cognitive substrates of thought disorder. I.
        Am J Psychiatry. 1998; 155: 1671-1676
        • Goldberg T.E.
        • Weinberger D.R.
        • Pliskin N.H.
        • Berman K.F.
        • Podd M.H.
        Recall memory deficit in schizophrenia.
        Schizophr Res. 1989; 2: 251-257
        • Gur R.E.
        • Mozley D.
        • Resnick S.M.
        • Levick S.
        • Erwin R.
        • Saykin A.J.
        • et al.
        Relations among clinical scales in schizophrenia.
        Am J Psychiatry. 1991; 148: 472-478
        • Hamilton M.
        A rating scale for depression.
        J Neurol Neurosurg Psychiatry. 1960; 23: 56-62
        • Heckers S.
        • Weiss A.P.
        • Alpert N.M.
        • Schacter D.L.
        Hippocampal and brain stem activation during word retrieval after repeated and semantic encoding.
        Cereb Cortex. 2002; 12: 900-907
        • Howard D.
        • Patterson K.
        The Pyramids and Palm Trees Test: A Test of Semantic Access from Words and Pictures. Thames Valley Test Company, Bury St. Edmunds, UK1992
        • Iddon J.L.
        • McKenna P.J.
        • Sahakian B.J.
        • Robbins T.W.
        Impaired generation and use of strategy in schizophrenia.
        Psychol Med. 1998; 28: 1049-1062
        • Johnson M.K.
        • Hashtroudi S.
        • Lindsay D.S.
        Source monitoring.
        Psychol Bull. 1993; 114: 3-28
        • Kintsch W.
        Recognition and free recall of organized lists.
        J Exp Psychol Gen. 1968; 78: 481-487
        • Koh S.
        • Kayton L.
        • Berry R.
        Mnemonic organization in young nonpsychotic schizophrenics.
        J Abnorm Psychol. 1973; 81: 299-310
        • Koh S.
        • Peterson R.
        Encoding orientation and the remembering of schizophrenic young adults.
        J Abnorm Psychol. 1978; 87: 303-313
        • Kohler C.
        • Gur R.C.
        • Swanson C.L.
        • Petty R.
        • Gur R.E.
        Depression in schizophrenia.
        Biol Psychiatry. 1998; 43: 165-172
        • McClain L.
        Encoding and retrieval in schizophrenic free recall.
        J Nerv Ment Dis. 1983; 171: 471-479
        • McKenna P.J.
        • Tamlyn D.
        • Lund C.E.
        • Mortimer A.M.
        • Hammond S.
        • Baddeley A.D.
        Amnesic syndrome in schizophrenia.
        Psychol Med. 1990; 20: 967-972
        • Moelter S.T.
        • Hill S.K.
        • Ragland J.D.
        • Lunardelli A.
        • Gur R.C.
        • Gur R.E.
        • et al.
        Controlled and automatic processing during animal word list generation in schizophrenia.
        Neuropsychology. 2001; 15: 492-501
      1. Nelson HE (1982): The National Adult Reading Test (NART). Windsor, Berkshire, UK: NFER-Nelson

        • Overall J.R.
        • Gorham D.
        The brief psychiatric rating scale.
        J Oper Psychiatry. 1980; ll: 48-64
        • Paulsen J.S.
        • Heaton R.K.
        • Sadek J.R.
        • Perry W.
        • Delis D.C.
        • Braff D.
        • et al.
        The nature of learning and memory impairments in schizophrenia.
        J Int Neuropsychol Soc. 1995; 1: 88-99
        • Rugg M.D.
        Memories are made of this.
        Science. 1998; 281: 1151-1152
        • Rund B.R.
        Distractibility and recall capability in schizophrenics.
        Schizophr Res. 1989; 2: 265-275
        • SAS Institute
        SAS/STAT Software, Version 8. SAS Institute Inc, Cary, NC1999
        • Saykin A.J.
        • Gur R.C.
        • Gur R.E.
        • Mozley D.
        • Mozley L.H.
        • Resnick S.M.
        • et al.
        Neuropsychological function in schizophrenia.
        Arch Gen Psychiatry. 1991; 48: 618-624
        • Saykin A.J.
        • Shtasel D.L.
        • Gur R.E.
        • Kester B.
        • Mozley L.H.
        • Stafiniak P.
        • et al.
        Neuropsychological deficits in neuroleptic naïve patients with first-episode schizophrenia.
        Arch Gen Psychiatry. 1994; 51: 124-131
        • Shtasel D.L.
        • Gur R.E.
        • Mozley P.D.
        • Richards J.
        • Taleff M.M.
        • Heimberg C.
        • et al.
        Volunteers for biomedical research.
        Arch Gen Psychiatry. 1991; 48: 1022-1025
        • Snodgrass J.G.
        • Corwin J.
        Pragmatics of measuring recognition memory.
        J Exp Psychol Gen. 1988; 117: 34-50
        • Sovani A.
        • Thatte S.
        Effects of psychosocial interventions on motor speed and accuracy of chronic positive, negative, and mixed schizophrenic symptoms.
        Int J Soc Psychiatry. 1998; 44: 117-126
        • Spitzer R.L.
        • Williams J.B.
        • Gibbon M.
        Instruction Manual for the Structured Clinical Interview for DSM-IV (SCID-P). New York State Psychiatric Institute, New York1996
        • Spitzer R.L.
        • Williams J.B.
        • Gibbon M.
        Structured Clinical Interview for DSM-IV. New York State Psychiatric Institute, New York1996
        • Stone M.
        • Gabrieli J.D.E.
        • Stebbins G.T.
        • Sullivan E.V.
        Working and strategic memory deficits in schizophrenia.
        Neuropsychology. 1998; 12: 278-288
        • Tulving E.
        Elements of Episodic Memory. Oxford University Press, Oxford, UK1983
        • Wagner A.D.
        • Schacter D.L.
        • Rotte M.
        • Koutstall W.
        • Maril A.
        • Dale A.M.
        • et al.
        Building memories.
        Science. 1998; 281: 1188-1191
        • Weiss A.P.
        • Dodson C.S.
        • Goff D.C.
        • Schacter D.L.
        • Heckers S.
        Intact suppression of increased false recognition in schizophrenia.
        Am J Psychiatry. 2002; 159: 1506-1513